This study was carried out in order to find out whether antineural antibodies had a role to play in perpetuating pre-existing nerve damage in leprosy. Indirect ELISA was carried out on sera from 20 leprosy patients and five normal controls using antigen prepared from peripheral nerves of a cured bacteriologically negative leprosy patient. None of the patients had significant levels of IgG antibodies whereas eight of them (40%) had significant levels of IgM antibodies. However, there was no correlation with duration of disease, treatment received, nerve enlargement or active neuritis. The nature of these antibodies is discussed.
BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/8576608?dopt=Abstract CN - Infolep Library - available DA - 1995 Jul-Sep IS - 3 J2 - Indian J Lepr LA - eng N2 -This study was carried out in order to find out whether antineural antibodies had a role to play in perpetuating pre-existing nerve damage in leprosy. Indirect ELISA was carried out on sera from 20 leprosy patients and five normal controls using antigen prepared from peripheral nerves of a cured bacteriologically negative leprosy patient. None of the patients had significant levels of IgG antibodies whereas eight of them (40%) had significant levels of IgM antibodies. However, there was no correlation with duration of disease, treatment received, nerve enlargement or active neuritis. The nature of these antibodies is discussed.
PY - 1995 SP - 293 EP - 300 T2 - Indian journal of leprosy TI - Role of antineural antibodies in perpetuation of a pre-existing peripheral nerve damage in leprosy. VL - 67 SN - 0254-9395 ER -