TY - JOUR KW - Adolescent KW - Adult KW - Aged KW - Bacteria KW - Child KW - Dapsone KW - Drug Therapy, Combination KW - Female KW - Follow-Up Studies KW - Humans KW - Leprostatic Agents KW - leprosy KW - Male KW - Middle Aged KW - Prednisolone KW - Time Factors KW - World Health Organization AU - Kishore B N AU - Shetty J N AB -

Sixty multibacillary leprosy patients with an average initial bacteriological index (BI) of 2.5 were followed up after they had completed the WHO--recommended multidrug therapy regularly till attaining bacteriological negativity. The minimum duration of treatment was two years as stipulated by WHO and the maximum duration for reaching negativity was seven years (mean 4.25 years). The minimum time for the attainment of bacteriological negativity was one year and the maximum was 6.75 years (mean 3.75 years). The higher the initial BI the longer was the time taken for the attainment of bacteriological negativity. The average fall of BI per year was 0.67. Dapsone monotherapy received before the commencement of MDT, prednisolone received during therapy and the type of leprosy did not have any effect on the time taken for bacteriological clearance. There was no relapse during the period of observation (mean 2.83 years). The site to attain negativity last was the ear lobe, in 95% of the cases.

BT - Indian journal of leprosy C1 - http://www.ncbi.nlm.nih.gov/pubmed/8576609?dopt=Abstract CN - Infolep Library - available DA - 1995 Jul-Sep IS - 3 J2 - Indian J Lepr LA - eng N2 -

Sixty multibacillary leprosy patients with an average initial bacteriological index (BI) of 2.5 were followed up after they had completed the WHO--recommended multidrug therapy regularly till attaining bacteriological negativity. The minimum duration of treatment was two years as stipulated by WHO and the maximum duration for reaching negativity was seven years (mean 4.25 years). The minimum time for the attainment of bacteriological negativity was one year and the maximum was 6.75 years (mean 3.75 years). The higher the initial BI the longer was the time taken for the attainment of bacteriological negativity. The average fall of BI per year was 0.67. Dapsone monotherapy received before the commencement of MDT, prednisolone received during therapy and the type of leprosy did not have any effect on the time taken for bacteriological clearance. There was no relapse during the period of observation (mean 2.83 years). The site to attain negativity last was the ear lobe, in 95% of the cases.

PY - 1995 SP - 301 EP - 8 T2 - Indian journal of leprosy TI - Bacterial clearance with WHO--recommended multidrug regimen for multibacillary leprosy. VL - 67 SN - 0254-9395 ER -