TY - JOUR KW - Adjuvants, Immunologic KW - Amino Acid Sequence KW - Enkephalin, D-Penicillamine (2,5)- KW - Enkephalin, Methionine KW - Enkephalins KW - Humans KW - Immunosuppressive Agents KW - In Vitro Techniques KW - leprosy KW - Lymphocyte Activation KW - Molecular Sequence Data KW - Opioid Peptides KW - Peptides, Cyclic KW - Receptors, Opioid, delta KW - Receptors, Opioid, mu KW - Rosette Formation KW - T-Lymphocytes KW - Tuberculosis, Pulmonary AU - Mazumder S AU - Nath I AU - Dhar M M AB -

The delta-opioid receptor selective [2-D-penicillamine-5-D-penicillamine] enkephalin (DPDPE) and the mu receptor selective Tyr-D-Orn-Phe-Asp-NH2 (TOPA) were found respectively, to have marked immunostimulant and immunosuppressant activities in both normal subjects and patients suffering from leprosy and tuberculosis. Antigen specific lymphoproliferation and numbers of rosette forming T cells were significantly (P < 0.05) enhanced on in vitro treatment with Met-enkephalin. This was further increased (P < 0.001) in the presence of the delta selective DPDPE. In contrast, treatment with mu selective TOPA inhibited lymphoproliferation substantially (P < 0.01) and rosette formation to a lesser extent.

BT - Immunology letters C1 - http://www.ncbi.nlm.nih.gov/pubmed/8384598?dopt=Abstract DA - 1993 Jan DO - 10.1016/0165-2478(93)90144-q IS - 1 J2 - Immunol. Lett. LA - eng N2 -

PY - 1993 SP - 33 EP - 8 T2 - Immunology letters TI - Immunomodulation of human T cell responses with receptor selective enkephalins. VL - 35 SN - 0165-2478 ER -