TY - JOUR
KW - Administration, Topical
KW - Adult
KW - Chronic Disease
KW - Female
KW - Humans
KW - leprosy
KW - Male
KW - Middle Aged
KW - Phenytoin
KW - Prospective Studies
KW - Sodium Chloride
KW - Ulcer
AU - Bansal N K
AB - <p><b>BACKGROUND: </b>Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient.</p><p><b>METHODS: </b>The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline.</p><p><b>RESULTS: </b>Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group.</p><p><b>CONCLUSIONS: </b>This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers.</p>
BT - International journal of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/8444537?dopt=Abstract
DA - 1993 Mar
DO - 10.1111/j.1365-4362.1993.tb02798.x
IS - 3
J2 - Int. J. Dermatol.
LA - eng
N2 - <p><b>BACKGROUND: </b>Trophic ulceration, one of the most common complications of leprosy, is disabling, distressing, and demoralizing for the patient.</p><p><b>METHODS: </b>The wound healing effects of topical phenytoin powder were compared with those of normal saline in a controlled in-patient study of 100 patients with 110 trophic leprosy ulcers of varying chronicity, over a 4-week study period. Fifty patients were assigned to the topical phenytoin group and 50 to saline therapy group. Ten patients had two ulcers each, and, in these cases, one ulcer was treated with phenytoin and the other with saline.</p><p><b>RESULTS: </b>Over the 4-week treatment period healthy granulation tissue appeared earlier, and mean percentage of ulcer volume reduction was greater, in the phenytoin group (72.1 +/- 19.9% versus 55.5 +/- 21.6%) compared with the control group.</p><p><b>CONCLUSIONS: </b>This difference was statistically significant at the level of P < 0.001. Phenytoin appears to be a useful agent for the promotion of healing of trophic leprosy ulcers.</p>
PY - 1993
SP - 210
EP - 3
T2 - International journal of dermatology
TI - Comparison of topical phenytoin with normal saline in the treatment of chronic trophic ulcers in leprosy.
VL - 32
SN - 0011-9059
ER -