TY - JOUR
KW - Bacterial Vaccines
KW - Erythema Nodosum
KW - Humans
KW - Immunotherapy
KW - Leprosy, lepromatous
AU - Zaheer S A
AU - Misra R S
AU - Sharma A K
AU - Beena K R
AU - Kar H K
AU - Mukherjee A
AU - Mukherjee R
AU - Walia R
AU - Talwar G P
AB - <p>Immunotherapy with Mycobacterium w (M.w) vaccine was given to 45 patients with multibacillary (MB) leprosy; 41 similarly classified patients served as controls. All patients received standard multidrug therapy (MDT). Incidence, severity and frequency of type 2 (ENL) reactional episodes were monitored in both groups in a follow-up extending up to 4 years. Reactions were seen in fewer vaccinated (10/37) BL and LL patients than in the control group (12/34). A total of 20 episodes were recorded in the vaccine group as against 29 in the controls, 75% of reactions were mild in vaccinated and 51.72% were mild in the control group patients, and 3 patients in the control group had more than 3 reactional episodes. None of the vaccinated patients showed this. No additional incidence of neuritis were seen among vaccinated individuals during reactional episodes.</p>
BT - Leprosy review
C1 - http://www.ncbi.nlm.nih.gov/pubmed/8464320?dopt=Abstract
CN - ZAHEER1993
DA - 1993 Mar
IS - 1
J2 - Lepr Rev
LA - eng
N2 - <p>Immunotherapy with Mycobacterium w (M.w) vaccine was given to 45 patients with multibacillary (MB) leprosy; 41 similarly classified patients served as controls. All patients received standard multidrug therapy (MDT). Incidence, severity and frequency of type 2 (ENL) reactional episodes were monitored in both groups in a follow-up extending up to 4 years. Reactions were seen in fewer vaccinated (10/37) BL and LL patients than in the control group (12/34). A total of 20 episodes were recorded in the vaccine group as against 29 in the controls, 75% of reactions were mild in vaccinated and 51.72% were mild in the control group patients, and 3 patients in the control group had more than 3 reactional episodes. None of the vaccinated patients showed this. No additional incidence of neuritis were seen among vaccinated individuals during reactional episodes.</p>
PY - 1993
SP - 7
EP - 14
T2 - Leprosy review
TI - Immunotherapy with Mycobacterium w vaccine decreases the incidence and severity of type 2 (ENL) reactions.
UR - http://leprev.ilsl.br/pdfs/1993/v64n1/pdf/v64n1a02.pdf
VL - 64
SN - 0305-7518
ER -