TY - JOUR
KW - Acyltransferases
KW - Animals
KW - Antigens, Bacterial
KW - BCG Vaccine
KW - Colony Count, Microbial
KW - Foot
KW - Immunization
KW - leprosy
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Nude
KW - Mycobacterium leprae
KW - Vaccines, Synthetic
AU - Ohara N
AU - Matsuoka M
AU - Nomaguchi H
AU - Naito M
AU - Yamada T
AB - <p>Immunization of mice with recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) which over-produces a putative protective antigen candidate, the A component of antigen 85 complex (Ag85A), reduced the multiplication of Mycobacterium leprae in the foot pads of mice. The inhibition by this rBCG (rBCG/85A) was more evident than that with parental BCG. Repeated rBCG/85A immunization significantly could reduce M. leplae multiplication in mice. This is first report of rBCG to control mycobacterial infection in animal model. Therefore, rBCG technique may be useful for the development of a more effective mycobacteria vaccine.</p>
BT - Vaccine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/10618524?dopt=Abstract
DA - 2000 Jan 31
DO - 10.1016/s0264-410x(99)00420-x
IS - 14
J2 - Vaccine
LA - eng
N2 - <p>Immunization of mice with recombinant Mycobacterium bovis Bacillus Calmette-Guérin (rBCG) which over-produces a putative protective antigen candidate, the A component of antigen 85 complex (Ag85A), reduced the multiplication of Mycobacterium leprae in the foot pads of mice. The inhibition by this rBCG (rBCG/85A) was more evident than that with parental BCG. Repeated rBCG/85A immunization significantly could reduce M. leplae multiplication in mice. This is first report of rBCG to control mycobacterial infection in animal model. Therefore, rBCG technique may be useful for the development of a more effective mycobacteria vaccine.</p>
PY - 2000
SP - 1294
EP - 7
T2 - Vaccine
TI - Inhibition of multiplication of Mycobacterium leprae in mouse foot pads by recombinant Bacillus Catmette-Guérin (BCG).
VL - 18
SN - 0264-410X
ER -