TY - JOUR
KW - Adult
KW - Antigens, CD
KW - Antigens, Surface
KW - Biomarkers
KW - Female
KW - Humans
KW - Immunoenzyme Techniques
KW - leprosy
KW - Male
KW - Receptors, Antigen, T-Cell
AU - Ishii N
AU - Sugita Y
AU - Kim S
AU - Sato K
AU - Nakajima H
AB - <p>Nine biopsy specimens from 3 tuberculoid (TT), 1 borderline tuberculoid (BT), 2 borderline (BB), 2 borderline lepromatous (BL), and 1 lepromatous (LL) patients were studied using immunoperoxidase procedures with monoclonal antibodies. In TT patients 4B4+, TCR alpha beta+, CD4+ T cells were dominant in dermal granulomas. In LL patient, dermal granulomas with 4B4+, TCR alpha beta+, CD4+ T cells and 2H4+, TCR alpha beta+, CD4+ T cells also had CD8+ T cells. The proportion of 4B4+ T cells increased in granulomas from LL to TT and 2H4+ T cells proportionately increased from TT to LL. TCR gamma delta+ T cells were detected only in BB and BL patients. However, there is no difference of staining pattern of ICAM-1 or LFA-1 antigen in any type of leprosy. These results indicate that the immunohistochemical pattern of T cells (CD4, CD8, 4B4, 2H4, TCR) may be useful in the diagnosis of the spectrum of leprosy.</p>
BT - Nihon Rai Gakkai zasshi
C1 - http://www.ncbi.nlm.nih.gov/pubmed/8282582?dopt=Abstract
DA - 1993 Jul
IS - 2
J2 - Nihon Rai Gakkai Zasshi
LA - jpn
N2 - <p>Nine biopsy specimens from 3 tuberculoid (TT), 1 borderline tuberculoid (BT), 2 borderline (BB), 2 borderline lepromatous (BL), and 1 lepromatous (LL) patients were studied using immunoperoxidase procedures with monoclonal antibodies. In TT patients 4B4+, TCR alpha beta+, CD4+ T cells were dominant in dermal granulomas. In LL patient, dermal granulomas with 4B4+, TCR alpha beta+, CD4+ T cells and 2H4+, TCR alpha beta+, CD4+ T cells also had CD8+ T cells. The proportion of 4B4+ T cells increased in granulomas from LL to TT and 2H4+ T cells proportionately increased from TT to LL. TCR gamma delta+ T cells were detected only in BB and BL patients. However, there is no difference of staining pattern of ICAM-1 or LFA-1 antigen in any type of leprosy. These results indicate that the immunohistochemical pattern of T cells (CD4, CD8, 4B4, 2H4, TCR) may be useful in the diagnosis of the spectrum of leprosy.</p>
PY - 1993
SP - 49
EP - 54
T2 - Nihon Rai Gakkai zasshi
TI - [Immunohistochemical analysis of cell surface markers in leprosy patients].
VL - 62
SN - 0386-3980
ER -