TY - JOUR KW - Animals KW - Anti-Infective Agents KW - Antitubercular Agents KW - Colony Count, Microbial KW - Disease Models, Animal KW - Fluoroquinolones KW - leprosy KW - Mice KW - Mice, Nude KW - Microbial Sensitivity Tests KW - Mycobacterium leprae KW - Ofloxacin KW - Quinolones AU - McDermott-Lancaster R D AU - Banerjee D K AB -

The activity of 25 mg/kg and 50 mg/kg sparfloxacin was measured against Mycobacterium leprae in normal (immunocompetent) mouse foot pads by the proportional bactericidal test. This was compared with the action of 25, 50, and 150 mg/kg ofloxacin by the same method. Sparfloxacin, at both concentrations, was found to be strongly bactericidal by this method, comparable to 150 mg/kg ofloxacin.

BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 -

http://www.ncbi.nlm.nih.gov/pubmed/8151193?dopt=Abstract

DA - 1993 Dec IS - 4 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -

The activity of 25 mg/kg and 50 mg/kg sparfloxacin was measured against Mycobacterium leprae in normal (immunocompetent) mouse foot pads by the proportional bactericidal test. This was compared with the action of 25, 50, and 150 mg/kg ofloxacin by the same method. Sparfloxacin, at both concentrations, was found to be strongly bactericidal by this method, comparable to 150 mg/kg ofloxacin.

PY - 1993 SP - 605 EP - 8 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Activity of sparfloxacin against Mycobacterium leprae measured by the proportional bactericidal test. UR - http://ila.ilsl.br/pdfs/v61n4a12.pdf VL - 61 SN - 0148-916X ER -