TY - JOUR KW - Antigen-Antibody Reactions KW - Antigens KW - Antigens, Bacterial KW - Humans KW - Injections, Intradermal KW - leprosy KW - Mycobacterium KW - Mycobacterium avium KW - Mycobacterium tuberculosis KW - Skin Tests KW - Tuberculin Test AU - Paul R C AU - Stanford J L AU - Carswell J W AB -

Groups of patients with lepromatous and tuberculoid leprosy and hospital staff from six leprosaria in East Africa and 'non-contact' groups of villagers or staff from general hospitals have been skin tested with 10 reagents. These were prepared by ultrasonic disintegration from M. tuberculosis, M. duvalii, M. chelonei and 7 other species identified in the Ugandan environment. Comparisons were made of the percentages of positive reactors in each study group for each reagent. The 'specific' defect of lepromatous patients was found to apply to a variable extent to six of the species tested, but not to M. tuberculosis, M. avium or M. 'A'. The defect applied most noticeably to M. nonchromogenicum and M. vaccae, suggesting that they are more closely related to M. leprae than are the other species tested. The reagent Chelonin produced unexpected and anomalous results in the lepromatous group. It is suggested that this was due to an unusually slow clearing of Arthus' reaction.

BT - The Journal of hygiene C1 - http://www.ncbi.nlm.nih.gov/pubmed/807619?dopt=Abstract DA - 1975 Aug DO - 10.1017/s0022172400047069 IS - 1 J2 - J Hyg (Lond) LA - eng N2 -

Groups of patients with lepromatous and tuberculoid leprosy and hospital staff from six leprosaria in East Africa and 'non-contact' groups of villagers or staff from general hospitals have been skin tested with 10 reagents. These were prepared by ultrasonic disintegration from M. tuberculosis, M. duvalii, M. chelonei and 7 other species identified in the Ugandan environment. Comparisons were made of the percentages of positive reactors in each study group for each reagent. The 'specific' defect of lepromatous patients was found to apply to a variable extent to six of the species tested, but not to M. tuberculosis, M. avium or M. 'A'. The defect applied most noticeably to M. nonchromogenicum and M. vaccae, suggesting that they are more closely related to M. leprae than are the other species tested. The reagent Chelonin produced unexpected and anomalous results in the lepromatous group. It is suggested that this was due to an unusually slow clearing of Arthus' reaction.

PY - 1975 SP - 57 EP - 68 T2 - The Journal of hygiene TI - Multiple skin testing in leprosy. VL - 75 SN - 0022-1724 ER -