TY - JOUR
KW - Amino Acid Sequence
KW - Base Sequence
KW - Humans
KW - Molecular Sequence Data
KW - Receptors, Antigen, T-Cell, gamma-delta
KW - Sarcoidosis
KW - T-Lymphocytes
AU - Tamura N
AU - Suzuki K
AU - YAMAMOTO T
AU - Kira S
AB - <p>T-cells recognize specific antigen (s) through the T-cell antigen receptors (TCR). gamma delta T-cells compose a minor population of the peripheral blood lymphocytes (PBL). These lymphocytes play a central role in recognizing the mycobacterial antigens and granuloma formation in tuberculosis and leprosy. Significant increase of gamma delta T-cells in PBL is observed in a subgroup of sarcoidosis. The majority of gamma delta T-cells showed V gamma 9/V delta 2 recombination, which is common in normal blood. To evaluate the clonality of the increased gamma delta T-cells in PBL, several V gamma 9 and V delta 2 cDNA clones were established. Analysis of V-J junctional sequences of V gamma 9 clones revealed oligoclonal expansion in some cases. Most of V delta 2 clones showed unique sequences. Although no clonal expansion of gamma delta T-cells were observed, TCR-gamma chain might recognize limited numbers of putative antigens in sarcoidosis.</p>
BT - Nihon rinsho. Japanese journal of clinical medicine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/8046826?dopt=Abstract
DA - 1994 Jun
IS - 6
J2 - Nippon Rinsho
LA - jpn
N2 - <p>T-cells recognize specific antigen (s) through the T-cell antigen receptors (TCR). gamma delta T-cells compose a minor population of the peripheral blood lymphocytes (PBL). These lymphocytes play a central role in recognizing the mycobacterial antigens and granuloma formation in tuberculosis and leprosy. Significant increase of gamma delta T-cells in PBL is observed in a subgroup of sarcoidosis. The majority of gamma delta T-cells showed V gamma 9/V delta 2 recombination, which is common in normal blood. To evaluate the clonality of the increased gamma delta T-cells in PBL, several V gamma 9 and V delta 2 cDNA clones were established. Analysis of V-J junctional sequences of V gamma 9 clones revealed oligoclonal expansion in some cases. Most of V delta 2 clones showed unique sequences. Although no clonal expansion of gamma delta T-cells were observed, TCR-gamma chain might recognize limited numbers of putative antigens in sarcoidosis.</p>
PY - 1994
SP - 1473
EP - 9
T2 - Nihon rinsho. Japanese journal of clinical medicine
TI - [The gamma delta T-cell receptors in sarcoidosis].
VL - 52
SN - 0047-1852
ER -