TY - JOUR
KW - Adolescent
KW - Adult
KW - Animals
KW - Antigens, Bacterial
KW - Child
KW - Female
KW - Foot
KW - Fusidic Acid
KW - Glycolipids
KW - Humans
KW - Leprosy, lepromatous
KW - Male
KW - Mice
KW - Microbial Sensitivity Tests
KW - Mycobacterium leprae
KW - polymerase chain reaction
KW - Skin
KW - Spirometry
KW - Time Factors
AU - Franzblau S G
AU - Chan G P
AU - Garcia-Ignacio B G
AU - Chavez V E
AU - Livelo J B
AU - Jimenez C L
AU - Parrilla M L
AU - Calvo R F
AU - Williams D L
AU - Gillis T P
AB - <p>Fusidic acid was assessed for antileprosy activity in nine lepromatous leprosy patients. Patients received fusidic acid at either 500 mg/day for 12 weeks or 750 mg/day for 4 weeks followed by 500 mg/day for 8 weeks. All patients showed time-dependent clinical improvement and decreases in bacillary morphological index, radiorespirometric activity and PCR signal, and in serum phenolic glycolipid I. Fusidic acid appears to be a weakly bactericidal antileprosy agent which may have a role in the multidrug treatment of leprosy pending an evaluation of lepra-reaction-suppressive activity.</p>
BT - Antimicrobial agents and chemotherapy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7979302?dopt=Abstract
DA - 1994 Jul
DO - 10.1128/aac.38.7.1651
IS - 7
J2 - Antimicrob. Agents Chemother.
LA - eng
N2 - <p>Fusidic acid was assessed for antileprosy activity in nine lepromatous leprosy patients. Patients received fusidic acid at either 500 mg/day for 12 weeks or 750 mg/day for 4 weeks followed by 500 mg/day for 8 weeks. All patients showed time-dependent clinical improvement and decreases in bacillary morphological index, radiorespirometric activity and PCR signal, and in serum phenolic glycolipid I. Fusidic acid appears to be a weakly bactericidal antileprosy agent which may have a role in the multidrug treatment of leprosy pending an evaluation of lepra-reaction-suppressive activity.</p>
PY - 1994
SP - 1651
EP - 4
T2 - Antimicrobial agents and chemotherapy
TI - Clinical trial of fusidic acid for lepromatous leprosy.
VL - 38
SN - 0066-4804
ER -