TY - JOUR
KW - Animals
KW - Axons
KW - Electric Stimulation
KW - Electrophysiology
KW - Female
KW - Granuloma
KW - Guinea Pigs
KW - Immunohistochemistry
KW - Leprosy, lepromatous
KW - Mycobacterium leprae
KW - Nerve Fibers
KW - Neuropeptides
KW - Organ Size
KW - Peripheral Nervous System Diseases
KW - Sciatic Nerve
KW - Tibial Nerve
AU - Blaquière G E
AU - Santamaria L
AU - Curtis J
AU - Terenghi G
AU - Polak J M
AU - Turk J L
AB - <p>Nerve damage, resembling that caused by Mycobacterium leprae in man, was created by the injection of cobalt-irradiated M. leprae organisms into the tibial nerve of guinea-pigs. Assessment of nerve damage was made by clinical, electrophysiological and morphometric means at intervals up to 13 weeks after injection. Quantitative immunohistochemical analysis of neuropeptide-containing fibres in the skin of the foot was also carried out. Significant nerve damage occurred 3 weeks after injection of M. leprae organisms. Motor and sensory functional loss peaked at 5 weeks after injection, and there was a significant decrease of peptide-immunoreactive nerves in all skin compartments. The nerve damage was self-limiting and functional recovery had occurred by 13 weeks. The model shows many of the features found in the nerve damage of treated leprosy patients.</p>
BT - Neuropathology and applied neurobiology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7936076?dopt=Abstract
DA - 1994 Jun
DO - 10.1111/j.1365-2990.1994.tb00968.x
IS - 3
J2 - Neuropathol. Appl. Neurobiol.
LA - eng
N2 - <p>Nerve damage, resembling that caused by Mycobacterium leprae in man, was created by the injection of cobalt-irradiated M. leprae organisms into the tibial nerve of guinea-pigs. Assessment of nerve damage was made by clinical, electrophysiological and morphometric means at intervals up to 13 weeks after injection. Quantitative immunohistochemical analysis of neuropeptide-containing fibres in the skin of the foot was also carried out. Significant nerve damage occurred 3 weeks after injection of M. leprae organisms. Motor and sensory functional loss peaked at 5 weeks after injection, and there was a significant decrease of peptide-immunoreactive nerves in all skin compartments. The nerve damage was self-limiting and functional recovery had occurred by 13 weeks. The model shows many of the features found in the nerve damage of treated leprosy patients.</p>
PY - 1994
SP - 261
EP - 71
T2 - Neuropathology and applied neurobiology
TI - A morphological and functional assessment of Mycobacterium leprae-induced nerve damage in a guinea-pig model of leprous neuritis.
VL - 20
SN - 0305-1846
ER -