TY - JOUR
KW - CD4-CD8 Ratio
KW - CD4-Positive T-Lymphocytes
KW - Humans
KW - Immunity, Cellular
KW - Immunophenotyping
KW - leprosy
KW - Leukocyte Count
KW - Receptors, Interleukin-2
KW - T-Lymphocyte Subsets
KW - T-Lymphocytes, Cytotoxic
KW - Tuberculosis, Cutaneous
AU - Sehgal V N
AU - Gupta R P
AU - Karmakar S
AU - Logani K B
AU - Jain S
AB - <p>The granulomas of lupus vulgaris (LV) were characterized by preponderance of CD4+ lymphocytes and a raised CD4+/CD8+ ratio. In contrast, in scrofuloderma (SF) the CD8+ T-lymphocyte subpopulation predominated and the CD4+/CD8+ ratio was significantly decreased. A higher percentage of lymphocytes expressed interleukin-2 receptor (IL-2R) in LV as compared with SF, indicating an activated cellular immune response in the former. Immunophenotypic changes in tuberculosis verrucosa cutis (TBVC) were intermediate between LV and SF. CD4+ lymphocytes were the main infiltrating T-cell type in borderline tuberculoid leprosy (BT), while CD8+ lymphocytes predominated in the granuloma of lepromatous lepromatous (LL). The CD4+/CD8+ ratio and percentage of lymphocytes expressing IL-2R was significantly higher in BT as compared with LL. These immunophenotypic findings suggest that in both cutaneous tuberculosis and leprosy there is a continuous spectrum with regard to cell-mediated immunity depending on the clinical presentation.</p>
BT - Clinical and experimental dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7955472?dopt=Abstract
DA - 1994 Jul
DO - 10.1111/j.1365-2230.1994.tb01202.x
IS - 4
J2 - Clin. Exp. Dermatol.
LA - eng
N2 - <p>The granulomas of lupus vulgaris (LV) were characterized by preponderance of CD4+ lymphocytes and a raised CD4+/CD8+ ratio. In contrast, in scrofuloderma (SF) the CD8+ T-lymphocyte subpopulation predominated and the CD4+/CD8+ ratio was significantly decreased. A higher percentage of lymphocytes expressed interleukin-2 receptor (IL-2R) in LV as compared with SF, indicating an activated cellular immune response in the former. Immunophenotypic changes in tuberculosis verrucosa cutis (TBVC) were intermediate between LV and SF. CD4+ lymphocytes were the main infiltrating T-cell type in borderline tuberculoid leprosy (BT), while CD8+ lymphocytes predominated in the granuloma of lepromatous lepromatous (LL). The CD4+/CD8+ ratio and percentage of lymphocytes expressing IL-2R was significantly higher in BT as compared with LL. These immunophenotypic findings suggest that in both cutaneous tuberculosis and leprosy there is a continuous spectrum with regard to cell-mediated immunity depending on the clinical presentation.</p>
PY - 1994
SP - 312
EP - 6
T2 - Clinical and experimental dermatology
TI - In situ characterization of lymphocytic immunophenotypes and interleukin-2 receptors in cutaneous tuberculosis and leprosy--a comparative evaluation.
VL - 19
SN - 0307-6938
ER -