This study was carried out to assess the role PGL-1 antibodies may have to play in assisting with early diagnosis in close contacts of leprosy patients. Blood samples were collected from patients and contacts. It was found that 6.9% of index cases and 1% of healthy contacts were positive for PGL-1 antibody. None of the healthy contacts developed clinical leprosy and all had become seronegative at follow-up. We conclude that screening for PGL-1 antibodies has a limited role in the screening of healthy contacts and may not be of use in low endemic areas.
BT - Leprosy review C1 - http://www.ncbi.nlm.nih.gov/pubmed/7861916?dopt=Abstract CN - Infolep Library - available DA - 1994 Dec DO - 10.5935/0305-7518.19940031 IS - 4 J2 - Lepr Rev LA - eng N2 -This study was carried out to assess the role PGL-1 antibodies may have to play in assisting with early diagnosis in close contacts of leprosy patients. Blood samples were collected from patients and contacts. It was found that 6.9% of index cases and 1% of healthy contacts were positive for PGL-1 antibody. None of the healthy contacts developed clinical leprosy and all had become seronegative at follow-up. We conclude that screening for PGL-1 antibodies has a limited role in the screening of healthy contacts and may not be of use in low endemic areas.
PY - 1994 SP - 300 EP - 4 T2 - Leprosy review TI - The role of IgM antiphenolic glycolipid-1 antibodies in assessing household contacts of leprosy patients in a low endemic area. UR - http://leprev.ilsl.br/pdfs/1994/v65n4/pdf/v65n4a03.pdf VL - 65 SN - 0305-7518 ER -