TY - JOUR KW - Animals KW - Antigens, Bacterial KW - Bacterial Vaccines KW - BCG Vaccine KW - leprosy KW - Male KW - Mice KW - Mice, Inbred CBA KW - Mycobacterium KW - Mycobacterium leprae AU - Iushin IM AU - Kalianina O V AB -

A protective potential of M. lufu against experimental lepra was studied in mice infected with M. leprae according to Shepard. 5 and 9 months after the inoculation quantitation of the causative agent in the animals' paws indicated a protective action of M. lufu which exceeded that of BCG, M. vaccae and M. leprae. High protective activity of M. lufu is due both to its antigenic composition similarity with M. leprae and influence on immune response regulation. It is suggested to use M. lufu for design of highly effective antilepra vaccine.

BT - Problemy tuberkuleza C1 - http://www.ncbi.nlm.nih.gov/pubmed/7777465?dopt=Abstract DA - 1995 IS - 2 J2 - Probl Tuberk LA - rus N2 -

A protective potential of M. lufu against experimental lepra was studied in mice infected with M. leprae according to Shepard. 5 and 9 months after the inoculation quantitation of the causative agent in the animals' paws indicated a protective action of M. lufu which exceeded that of BCG, M. vaccae and M. leprae. High protective activity of M. lufu is due both to its antigenic composition similarity with M. leprae and influence on immune response regulation. It is suggested to use M. lufu for design of highly effective antilepra vaccine.

PY - 1995 SP - 47 EP - 8 T2 - Problemy tuberkuleza TI - [Protective properties of M. lufu in experimental leprosy]. SN - 0032-9533 ER -