The clinical spectrum of leprosy reflects the diverse nature of human immune responses to Mycobacterium leprae. The clinical presentations correlate with the level of cell-mediated immunity against M. leprae. Cell-mediated immunity, as assessed by the Mitsuda reaction, is positive in tuberculoid patients and negative in lepromatous patients. In contrast, humoral immunity, as assessed by anti-M. leprae antibodies is greatest in lepromatous patients. The inverse correlation between cell-mediated immunity can be explained on the basis of the local cytokine pattern.
BT - Nihon Rai Gakkai zasshi C1 - http://www.ncbi.nlm.nih.gov/pubmed/7592165?dopt=Abstract CN - MODLIN1995 DA - 1995 Jul IS - 2 J2 - Nihon Rai Gakkai Zasshi LA - eng N2 -The clinical spectrum of leprosy reflects the diverse nature of human immune responses to Mycobacterium leprae. The clinical presentations correlate with the level of cell-mediated immunity against M. leprae. Cell-mediated immunity, as assessed by the Mitsuda reaction, is positive in tuberculoid patients and negative in lepromatous patients. In contrast, humoral immunity, as assessed by anti-M. leprae antibodies is greatest in lepromatous patients. The inverse correlation between cell-mediated immunity can be explained on the basis of the local cytokine pattern.
PY - 1995 SP - 85 EP - 8 T2 - Nihon Rai Gakkai zasshi TI - Cytokine responses in leprosy lesions. VL - 64 SN - 0386-3980 ER -