TY - JOUR KW - Administration, Oral KW - Ampicillin KW - Animals KW - Drug Therapy, Combination KW - Hindlimb KW - leprosy KW - Mice KW - Mice, Inbred BALB C KW - Mice, Nude KW - Models, Biological KW - Mycobacterium leprae KW - Sulbactam AU - Randhawa B AU - Harris E B AU - Prabhakaran K AB -

We reported previously that an injectable form of ampicillin/sulbactam, Unasyn, was bactericidal to Mycobacterium leprae multiplying in mouse foot pads. In this study, we examined the effect of an orally active form of ampicillin/sulbactam, Sultamicillin, on the growth of M. leprae in mice. Three concentrations of the drug, mixed with the feed, were administered from the start until the mice were killed at 6 months; 0.01% of the drug inhibited bacterial growth by 54%, 0.10% by 74% and 0.20% by 93%. To test whether oral ampicillin/sulbactam was bactericidal, 0.50% of the drug, mixed with the feed, was administered to experimentally infected mice for 3 months during the logarithmic phase of bacterial growth, and then discontinued; multiplication of the bacilli was monitored monthly for the next 8 months. The results showed that orally active ampicillin/sulbactam is bactericidal to M. leprae.

BT - The Journal of antimicrobial chemotherapy C1 - http://www.ncbi.nlm.nih.gov/pubmed/10473236?dopt=Abstract DA - 1999 Aug DO - 10.1093/jac/44.2.279 IS - 2 J2 - J. Antimicrob. Chemother. LA - eng N2 -

We reported previously that an injectable form of ampicillin/sulbactam, Unasyn, was bactericidal to Mycobacterium leprae multiplying in mouse foot pads. In this study, we examined the effect of an orally active form of ampicillin/sulbactam, Sultamicillin, on the growth of M. leprae in mice. Three concentrations of the drug, mixed with the feed, were administered from the start until the mice were killed at 6 months; 0.01% of the drug inhibited bacterial growth by 54%, 0.10% by 74% and 0.20% by 93%. To test whether oral ampicillin/sulbactam was bactericidal, 0.50% of the drug, mixed with the feed, was administered to experimentally infected mice for 3 months during the logarithmic phase of bacterial growth, and then discontinued; multiplication of the bacilli was monitored monthly for the next 8 months. The results showed that orally active ampicillin/sulbactam is bactericidal to M. leprae.

PY - 1999 SP - 279 EP - 81 T2 - The Journal of antimicrobial chemotherapy TI - Bactericidal action of oral ampicillin/sulbactam against Mycobacterium leprae. VL - 44 SN - 0305-7453 ER -