TY - JOUR
KW - Antigen Presentation
KW - Antigen-Presenting Cells
KW - Antigens, CD
KW - Antigens, CD1
KW - Carbohydrate Conformation
KW - Carbohydrate Sequence
KW - Cell Line
KW - Humans
KW - Interferon-gamma
KW - Interleukin-4
KW - leprosy
KW - Lipopolysaccharides
KW - Lymphocyte Activation
KW - Molecular Sequence Data
KW - Mycobacterium leprae
KW - Phosphatidylinositols
KW - Receptors, Antigen, T-Cell, alpha-beta
KW - Species Specificity
KW - T-Lymphocytes, Cytotoxic
AU - Sieling P A
AU - Chatterjee D
AU - Porcelli S A
AU - Prigozy T I
AU - Mazzaccaro R J
AU - Soriano T
AU - Bloom B R
AU - Brenner M B
AU - Kronenberg M
AU - Brennan P J
AB - <p>It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.</p>
BT - Science (New York, N.Y.)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7542404?dopt=Abstract
DA - 1995 Jul 14
DO - 10.1126/science.7542404
IS - 5221
J2 - Science
LA - eng
N2 - <p>It has long been the paradigm that T cells recognize peptide antigens presented by major histocompatibility complex (MHC) molecules. However, nonpeptide antigens can be presented to T cells by human CD1b molecules, which are not encoded by the MHC. A major class of microbial antigens associated with pathogenicity are lipoglycans. It is shown here that human CD1b presents the defined mycobacterial lipoglycan lipoarabinomannan (LAM) to alpha beta T cell receptor-bearing lymphocytes. Presentation of these lipoglycan antigens required internalization and endosomal acidification. The T cell recognition required mannosides with alpha(1-->2) linkages and a phosphotidylinositol unit. T cells activated by LAM produced interferon gamma and were cytolytic. Thus, an important class of microbial molecules, the lipoglycans, is a part of the universe of foreign antigens recognized by human T cells.</p>
PY - 1995
SP - 227
EP - 30
T2 - Science (New York, N.Y.)
TI - CD1-restricted T cell recognition of microbial lipoglycan antigens.
VL - 269
SN - 0036-8075
ER -