TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Biological Assay
KW - Humans
KW - Leprostatic Agents
KW - leprosy
KW - Middle Aged
KW - Mycobacterium bovis
KW - Nerve Tissue
KW - Oxidation-Reduction
KW - Palmitic Acids
KW - Rifampin
KW - Tibial Nerve
AU - Guebre-Xabier M
AU - Shannon E J
AU - Kazen R
AU - Kebret Z
AU - Frommel D
AB - <p>Rifampin in picogram quantities inhibited the ability of Mycobacterium bovis 44 BCG P3 to release 14CO2 from the oxidation of [14C]palmitic acid. By using these mycobacteria in a bioassay, samples of serum and posterior tibial nerve were assayed for inhibitory concentrations of rifampin. Within 8 to 12 h after ingestion of 600 mg of rifampin, the drug was detected in eight patients in concentrations ranging from 0.52 to 4.1 micrograms/ml in serum and in concentrations ranging from 0.6 to 6.3 ng/mg in posterior tibial nerve fiber tissue.</p>
BT - Antimicrobial agents and chemotherapy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7486936?dopt=Abstract
DA - 1995 Aug
DO - 10.1128/aac.39.8.1866
IS - 8
J2 - Antimicrob. Agents Chemother.
LA - eng
N2 - <p>Rifampin in picogram quantities inhibited the ability of Mycobacterium bovis 44 BCG P3 to release 14CO2 from the oxidation of [14C]palmitic acid. By using these mycobacteria in a bioassay, samples of serum and posterior tibial nerve were assayed for inhibitory concentrations of rifampin. Within 8 to 12 h after ingestion of 600 mg of rifampin, the drug was detected in eight patients in concentrations ranging from 0.52 to 4.1 micrograms/ml in serum and in concentrations ranging from 0.6 to 6.3 ng/mg in posterior tibial nerve fiber tissue.</p>
PY - 1995
SP - 1866
EP - 70
T2 - Antimicrobial agents and chemotherapy
TI - Early detection of rifampin in human nerve tissue after an oral dose of 600 milligrams.
VL - 39
SN - 0066-4804
ER -