TY - JOUR KW - African Continental Ancestry Group KW - Alleles KW - Blood Proteins KW - Genetic Code KW - Haptoglobins KW - Humans KW - leprosy KW - Phenotype KW - Polymorphism, Genetic KW - South Africa KW - Statistics as Topic KW - Transferrin AU - Hitzeroth H W AU - Walter H AU - Hilling M AB -

The phenotype frequencies of the serum protein polymorphisms Hp, Gc, Tf, Gm and Inv were determined on a sample of 250 South African Negroes with leprosy. These results were compared with data derived from 918-977 (depending on the polymorphism tested) healthy Negro controls of similar geographical and ethnic origin, in order to determine whether or not any association existed between specific phenotypes and the occurrence of leprosy. The data derived from the present study were also compared with those of similar comparative analyses on African and non-African populations. Because of the contradictory results between samples with regard to the polymorphisms Hp, Gc and Inv, an association of any of these phenotypes with leprosy appears to be highly improbable. With regard to the polymorphisms Tf and Gm, however, such associations cannot be ruled out. The questions arising from the results are discussed.

BT - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde C1 - http://www.ncbi.nlm.nih.gov/pubmed/741274?dopt=Abstract DA - 1978 Oct 14 IS - 16 J2 - S. Afr. Med. J. LA - eng N2 -

The phenotype frequencies of the serum protein polymorphisms Hp, Gc, Tf, Gm and Inv were determined on a sample of 250 South African Negroes with leprosy. These results were compared with data derived from 918-977 (depending on the polymorphism tested) healthy Negro controls of similar geographical and ethnic origin, in order to determine whether or not any association existed between specific phenotypes and the occurrence of leprosy. The data derived from the present study were also compared with those of similar comparative analyses on African and non-African populations. Because of the contradictory results between samples with regard to the polymorphisms Hp, Gc and Inv, an association of any of these phenotypes with leprosy appears to be highly improbable. With regard to the polymorphisms Tf and Gm, however, such associations cannot be ruled out. The questions arising from the results are discussed.

PY - 1978 SP - 653 EP - 8 T2 - South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde TI - Genetic markers and leprosy in South African negroes. Part I. Serum protein polymorphisms. VL - 54 SN - 0256-9574 ER -