TY - JOUR KW - Adolescent KW - Adult KW - BCG Vaccine KW - Child KW - Child, Preschool KW - Environmental Exposure KW - Humans KW - Immunity, Cellular KW - Infant KW - Infant, Newborn KW - leprosy KW - Mycobacterium KW - Tuberculin Test KW - Tuberculosis AU - Stanford J L AU - Shield M J AU - Rook G A AB -

A proposal is made that there are 2 mechanisms of cell mediated response to mycobacteria, both of which produce positive tuberculin tests and that one of them is more protective against mycobacterial infection than is the other. These are referred to respectively as the Listeria-type and the Koch-type of responses. Contact with environmental mycobacteria will induce one or other of these types of response and BCG vaccination will enhance it. Thus in those places where the environmental species prime for the Listeria-type of response subsequent BCG vaccination will afford good protection from both tuberculosis and leprosy. Where the Koch-type of response frequently results from environmental contact BCG will be ineffective. Evidence if presented that a large contact with Mycobacterium scrofulaceum is prejudicial to at least one marker of BCG efficacy in Burma.

BT - Tubercle C1 - http://www.ncbi.nlm.nih.gov/pubmed/7268920?dopt=Abstract DA - 1981 Mar DO - 10.1016/0041-3879(81)90037-4 IS - 1 J2 - Tubercle LA - eng N2 -

A proposal is made that there are 2 mechanisms of cell mediated response to mycobacteria, both of which produce positive tuberculin tests and that one of them is more protective against mycobacterial infection than is the other. These are referred to respectively as the Listeria-type and the Koch-type of responses. Contact with environmental mycobacteria will induce one or other of these types of response and BCG vaccination will enhance it. Thus in those places where the environmental species prime for the Listeria-type of response subsequent BCG vaccination will afford good protection from both tuberculosis and leprosy. Where the Koch-type of response frequently results from environmental contact BCG will be ineffective. Evidence if presented that a large contact with Mycobacterium scrofulaceum is prejudicial to at least one marker of BCG efficacy in Burma.

PY - 1981 SP - 55 EP - 62 T2 - Tubercle TI - How environmental mycobacteria may predetermine the protective efficacy of BCG. VL - 62 SN - 0041-3879 ER -