TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Aged, 80 and over
KW - Biopsy, Needle
KW - Child
KW - Collagen
KW - Elastin
KW - Female
KW - Giant Cells
KW - Humans
KW - leprosy
KW - Leprosy, Borderline
KW - Leprosy, Tuberculoid
KW - Male
KW - Middle Aged
KW - Phagocytosis
KW - Prospective Studies
KW - Reference Values
KW - Retrospective Studies
KW - Skin
AU - Malik A
AU - Bhatia A
AU - Singh N
AU - Bhattacharya S N
AU - Arora V K
AB - <p><b>OBJECTIVE: </b>To define diagnostic cytomorphologic features of reactions in leprosy.</p><p><b>STUDY DESIGN: </b>Part-retrospective, part-prospective, single-blind, controlled study of the applicability of fine needle aspiration cytology in the diagnosis of reactions in leprosy. Cytomorphologic features were compared in 42 clinically diagnosed patients with reactions in leprosy with those in a control group of patients with nonreactional leprosy. The study groups included type 1 and type 2 reactions in 35 and 9 patients, respectively. May-Grünwald-Giemsa and Ziehl-Neelsen staining methods were employed.</p><p><b>RESULTS: </b>Statistically significant (P < .01) cytomorphologic features of type 1 reaction were the presence of fragments of collagen and elastin; giant cells; giant cells exhibiting elastin phagocytosis; loose, epithelioid cell granulomas; and fibroblasts. Type 2 reaction was characterized in aspirates by the presence of an abundance of neutrophils in a background of lepromatous leprosy (P < .01).</p><p><b>CONCLUSION: </b>Criteria that are used in histopathology for the diagnosis of leprosy reactions can be applied satisfactorily to cytologic smears. A good correlation between clinical diagnosis and cytomorphology can be achieved. Multiple-site aspirates from the skin, nerve and lymph nodes are helpful in substantiating the diagnosis.</p>
BT - Acta cytologica
C1 - http://www.ncbi.nlm.nih.gov/pubmed/10518129?dopt=Abstract
DA - 1999 Sep-Oct
DO - 10.1159/000331290
IS - 5
J2 - Acta Cytol.
LA - eng
N2 - <p><b>OBJECTIVE: </b>To define diagnostic cytomorphologic features of reactions in leprosy.</p><p><b>STUDY DESIGN: </b>Part-retrospective, part-prospective, single-blind, controlled study of the applicability of fine needle aspiration cytology in the diagnosis of reactions in leprosy. Cytomorphologic features were compared in 42 clinically diagnosed patients with reactions in leprosy with those in a control group of patients with nonreactional leprosy. The study groups included type 1 and type 2 reactions in 35 and 9 patients, respectively. May-Grünwald-Giemsa and Ziehl-Neelsen staining methods were employed.</p><p><b>RESULTS: </b>Statistically significant (P < .01) cytomorphologic features of type 1 reaction were the presence of fragments of collagen and elastin; giant cells; giant cells exhibiting elastin phagocytosis; loose, epithelioid cell granulomas; and fibroblasts. Type 2 reaction was characterized in aspirates by the presence of an abundance of neutrophils in a background of lepromatous leprosy (P < .01).</p><p><b>CONCLUSION: </b>Criteria that are used in histopathology for the diagnosis of leprosy reactions can be applied satisfactorily to cytologic smears. A good correlation between clinical diagnosis and cytomorphology can be achieved. Multiple-site aspirates from the skin, nerve and lymph nodes are helpful in substantiating the diagnosis.</p>
PY - 1999
SP - 771
EP - 6
T2 - Acta cytologica
TI - Fine needle aspiration cytology of reactions in leprosy.
VL - 43
SN - 0001-5547
ER -