TY - JOUR KW - Adolescent KW - Adult KW - Cell Migration Inhibition KW - Chemotaxis, Leukocyte KW - Female KW - Glucosamine KW - Humans KW - leprosy KW - Leukocyte Count KW - Male KW - Middle Aged KW - Monocytes KW - Nitroblue Tetrazolium KW - Receptors, Complement KW - Receptors, Fc AU - Masuda A AU - Scheinberg M A AB -

The activities of monocytes from lepromatous (LL) and tuberculoid (TT) leprosy patients were studied in a variety of in vitro systems. In assays of receptor activity, increased densities of Fc and C3b receptor sites were observed in monocytes of LL and TT patients as compared to normals. No differences were observed between the polar forms of the disease. Similar results were obtained in the nitroblue tetrazolium (NBT) reduction test. Glucosamine incorporation by monocytes from LL and TT patients was not significantly different from that by monocytes from normal controls. A diminished monocyte spontaneous migration and chemotactic activity to lymphocyte derived chemotactic factor (LDCF) was found in both forms of the disease. Plasma inhibitory factor of monocyte chemotaxis was more evident in the lepromatous form of the disease.

BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 -

http://www.ncbi.nlm.nih.gov/pubmed/7192267?dopt=Abstract

DA - 1980 Sep IS - 3 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -

The activities of monocytes from lepromatous (LL) and tuberculoid (TT) leprosy patients were studied in a variety of in vitro systems. In assays of receptor activity, increased densities of Fc and C3b receptor sites were observed in monocytes of LL and TT patients as compared to normals. No differences were observed between the polar forms of the disease. Similar results were obtained in the nitroblue tetrazolium (NBT) reduction test. Glucosamine incorporation by monocytes from LL and TT patients was not significantly different from that by monocytes from normal controls. A diminished monocyte spontaneous migration and chemotactic activity to lymphocyte derived chemotactic factor (LDCF) was found in both forms of the disease. Plasma inhibitory factor of monocyte chemotaxis was more evident in the lepromatous form of the disease.

PY - 1980 SP - 254 EP - 9 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Peripheral blood monocyte function in leprosy patients. UR - http://ila.ilsl.br/pdfs/v48n3a02.pdf VL - 48 SN - 0148-916X ER -