TY - JOUR
KW - Adult
KW - Anti-HIV Agents
KW - Antiretroviral Therapy, Highly Active
KW - Brazil
KW - Cohort Studies
KW - Comorbidity
KW - Granuloma
KW - HIV Infections
KW - Humans
KW - leprosy
KW - Longitudinal studies
KW - Male
KW - Middle Aged
KW - Prevalence
KW - Severity of Illness Index
KW - Young Adult
AU - Talhari C
AU - Mira M
AU - Massone C
AU - Braga A
AU - Chrusciak-Talhari A
AU - Santos M
AU - Orsi AT
AU - Matsuo C
AU - Rabelo R
AU - Nogueira L
AU - Lima Ferreira LC
AU - Ribeiro-Rodrigues R
AU - Talhari S
AB - <p><b>BACKGROUND: </b>Although awareness of the relevance of leprosy and human immunodeficiency virus (HIV) coinfection is increasing worldwide, several aspects of this co-occurrence are not fully understood.</p><p><b>METHODS: </b>We describe clinical, pathological, immunological, and therapeutic long-term follow-up of a cohort of 25 individuals with leprosy and HIV infection from Manaus, Amazonas.</p><p><b>RESULTS: </b>Careful description of our cohort indicates a higher prevalence of leprosy in an HIV-positive population than that in the general population. We also observed upgrading shifting of leprosy clinical forms after initiation of highly active antiretroviral therapy and multidrug therapy and an impact of HIV infection on leprosy granuloma formation, among other features.</p><p><b>CONCLUSION: </b>Taken together, these new insights allow the proposition of a classification system that includes (1) leprosy and HIV true coinfection, (2) opportunistic leprosy disease, and (3) leprosy related to highly active antiretroviral therapy.</p>
BT - The Journal of infectious diseases
C1 - http://www.ncbi.nlm.nih.gov/pubmed/20565258?dopt=Abstract
DA - 2010 Aug 15
DO - 10.1086/653839
IS - 3
J2 - J. Infect. Dis.
LA - eng
N2 - <p><b>BACKGROUND: </b>Although awareness of the relevance of leprosy and human immunodeficiency virus (HIV) coinfection is increasing worldwide, several aspects of this co-occurrence are not fully understood.</p><p><b>METHODS: </b>We describe clinical, pathological, immunological, and therapeutic long-term follow-up of a cohort of 25 individuals with leprosy and HIV infection from Manaus, Amazonas.</p><p><b>RESULTS: </b>Careful description of our cohort indicates a higher prevalence of leprosy in an HIV-positive population than that in the general population. We also observed upgrading shifting of leprosy clinical forms after initiation of highly active antiretroviral therapy and multidrug therapy and an impact of HIV infection on leprosy granuloma formation, among other features.</p><p><b>CONCLUSION: </b>Taken together, these new insights allow the proposition of a classification system that includes (1) leprosy and HIV true coinfection, (2) opportunistic leprosy disease, and (3) leprosy related to highly active antiretroviral therapy.</p>
PY - 2010
SP - 345
EP - 54
T2 - The Journal of infectious diseases
TI - Leprosy and HIV coinfection: a clinical, pathological, immunological, and therapeutic study of a cohort from a Brazilian referral center for infectious diseases.
UR - http://jid.oxfordjournals.org/content/202/3/345.full.pdf+html?sid=bdeaafc9-0d5f-4023-a403-d5a466936be1
VL - 202
SN - 1537-6613
ER -