A dramatic alteration from clinically subpolar tuberculoid leprosy toward subpolar lepromatous leprosy was observed during griseofulvin therapy in a 29-year-old man, despite apparently normal cell-mediated immunity. To our knowledge, this is the first reported case of a downgrading reaction associated with griseofulvin. It is possible that this reaction was due to inhibition of polymorphonuclear leukocyte chemotaxis by griseofulvin.
BT - Archives of dermatology C1 - http://www.ncbi.nlm.nih.gov/pubmed/7138049?dopt=Abstract DA - 1982 Nov IS - 11 J2 - Arch Dermatol LA - eng N2 -A dramatic alteration from clinically subpolar tuberculoid leprosy toward subpolar lepromatous leprosy was observed during griseofulvin therapy in a 29-year-old man, despite apparently normal cell-mediated immunity. To our knowledge, this is the first reported case of a downgrading reaction associated with griseofulvin. It is possible that this reaction was due to inhibition of polymorphonuclear leukocyte chemotaxis by griseofulvin.
PY - 1982 SP - 909 EP - 12 T2 - Archives of dermatology TI - Leprosy downgrading reaction associated with griseofulvin. VL - 118 SN - 0003-987X ER -