TY - JOUR
KW - Animals
KW - Dapsone
KW - Drug Interactions
KW - Drug Therapy, Combination
KW - Isoniazid
KW - Isonicotinic Acids
KW - leprosy
KW - Mice
KW - Mycobacterium
KW - Mycobacterium leprae
KW - Prothionamide
AU - Pattyn S R
AU - Portaels F
AU - Van Loo G
AU - Van den Breen L
AB - <p>No additive effect was found at the addition of isoniazid to either dapsone or protionamide against M. leprae and against highly dapsone-sensitive in vitro growing Mycobacterium sp. strains. It is concluded that the indication of the administration of isoniazid in leprosy is extremely limited and could only be envisaged as a companion drug in combined therapy of dapsone-resistant multibacillary leprosy in light-skinned people, when aminoglycosides cannot be administered.</p>
BT - Arzneimittel-Forschung
C1 - http://www.ncbi.nlm.nih.gov/pubmed/7037011?dopt=Abstract
DA - 1981
IS - 12
J2 - Arzneimittelforschung
LA - eng
N2 - <p>No additive effect was found at the addition of isoniazid to either dapsone or protionamide against M. leprae and against highly dapsone-sensitive in vitro growing Mycobacterium sp. strains. It is concluded that the indication of the administration of isoniazid in leprosy is extremely limited and could only be envisaged as a companion drug in combined therapy of dapsone-resistant multibacillary leprosy in light-skinned people, when aminoglycosides cannot be administered.</p>
PY - 1981
SP - 2155
EP - 7
T2 - Arzneimittel-Forschung
TI - Activity of the combination of isoniazid, protionamide and dapsone against Mycobacterium leprae and some other mycobacteria.
VL - 31
SN - 0004-4172
ER -