TY - JOUR
KW - Animals
KW - Antigens, Bacterial
KW - Bacterial Vaccines
KW - Interferon-gamma
KW - leprosy
KW - Mice
KW - Mice, Inbred BALB C
KW - Mice, Nude
KW - Mycobacterium leprae
KW - Spleen
AU - Naito M
AU - Matsuoka M
AU - Ohara N
AU - Nomaguchi H
AU - Yamada T
AB - <p>The proteins in culture filtrate derived from Bacillus Calmette-Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon gamma (IFNgamma) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection.</p>
BT - Vaccine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/10580191?dopt=Abstract
DA - 1999 Dec 10
DO - 10.1016/s0264-410x(99)00327-8
IS - 9-10
J2 - Vaccine
LA - eng
N2 - <p>The proteins in culture filtrate derived from Bacillus Calmette-Guérin (BCG) were examined for protection against infection by Mycobacterium leprae. Immunization with the major secreted proteins, antigen 85 complex (Ag 85) A, B and C, induced effective protective immunity against multiplication of M. leprae in the foot pads of mice. The most effective protection was observed when mice were immunized with Ag 85A. A single immunization with Ag 85 could induce antigen-specific interferon gamma (IFNgamma) synthesis and more effective protection than live BCG vaccine. This study demonstrates that Ag 85 is an important immunoprotective molecule against leprosy infection.</p>
PY - 1999
SP - 795
EP - 8
T2 - Vaccine
TI - The antigen 85 complex vaccine against experimental Mycobacterium leprae infection in mice.
VL - 18
SN - 0264-410X
ER -