When macrophages from lepromatous leprosy patients are exposed to M. leprae, the macrophages show reduced protein synthesis. Such a phenomenon is not seen with macrophages from tuberculoid patients or normal individuals. M. leprae phagocytized by Schwann cells affect the incorporation of DNA precursor in the cells, leading to failure of Schwann cell association with axons in in vitro cultures. These 2 observations form a basis of proposing that basic biochemical events take place when M. leprae are associated with host cells, which in turn can be amplified to physiologically functional defects.
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 - http://www.ncbi.nlm.nih.gov/pubmed/6995358?dopt=Abstract DA - 1980 Jun IS - 2 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -When macrophages from lepromatous leprosy patients are exposed to M. leprae, the macrophages show reduced protein synthesis. Such a phenomenon is not seen with macrophages from tuberculoid patients or normal individuals. M. leprae phagocytized by Schwann cells affect the incorporation of DNA precursor in the cells, leading to failure of Schwann cell association with axons in in vitro cultures. These 2 observations form a basis of proposing that basic biochemical events take place when M. leprae are associated with host cells, which in turn can be amplified to physiologically functional defects.
PY - 1980 SP - 167 EP - 71 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Biochemical alteration in cells following phagocytosis of M. leprae--the consequence--a basic concept. VL - 48 SN - 0148-916X ER -