TY - JOUR KW - Adult KW - Aged KW - Complement C3 KW - Complement C3-C5 Convertases KW - Complement C3c KW - Complement C4 KW - Erythema Nodosum KW - Female KW - Humans KW - leprosy KW - Male KW - Middle Aged KW - T-Lymphocytes AU - Izumi S AU - Sugiyama K AU - Matsumoto Y AU - Nagai T AB -

Eighty-six leprosy patients (49 active lepromatous, 24 inactive lepromatous 7 borderline, and 6 tuberculoid) and nine healthy controls were examined for numerical changes in T cell subsets (T gamma and T mu), and complement levels in peripheral blood to determine the roles of T cell subsets and complement in the etiology of leprosy. The percentage and number of T gamma and T mu showed no significant differences among the different clinical groups, but 4 out of 49 active lepromatous, 3 out of 24 inactive lepromatous and 3 out of 7 borderline cases showed a high prcentage of T gamma cells. Serum concentrations of C4, C3c, and C3 activator, an important factor in the alternative pathway of complement activation, were not significantly different among the groups. However, C3 activator and C3c concentrations were significantly high in active lepromatous patients complicated by an immune complex disease called "erythema nodosum leprosum" (ENL) compared with ENL-free active lepromatous leprosy.

BT - Microbiology and immunology C1 - http://www.ncbi.nlm.nih.gov/pubmed/6968392?dopt=Abstract DA - 1980 DO - 10.1111/j.1348-0421.1980.tb02874.x IS - 8 J2 - Microbiol. Immunol. LA - eng N2 -

Eighty-six leprosy patients (49 active lepromatous, 24 inactive lepromatous 7 borderline, and 6 tuberculoid) and nine healthy controls were examined for numerical changes in T cell subsets (T gamma and T mu), and complement levels in peripheral blood to determine the roles of T cell subsets and complement in the etiology of leprosy. The percentage and number of T gamma and T mu showed no significant differences among the different clinical groups, but 4 out of 49 active lepromatous, 3 out of 24 inactive lepromatous and 3 out of 7 borderline cases showed a high prcentage of T gamma cells. Serum concentrations of C4, C3c, and C3 activator, an important factor in the alternative pathway of complement activation, were not significantly different among the groups. However, C3 activator and C3c concentrations were significantly high in active lepromatous patients complicated by an immune complex disease called "erythema nodosum leprosum" (ENL) compared with ENL-free active lepromatous leprosy.

PY - 1980 SP - 733 EP - 40 T2 - Microbiology and immunology TI - Numerical changes in T cell subsets (T gamma and T mu) in leprosy patients. VL - 24 SN - 0385-5600 ER -