Non-immunosuppressed Swiss mice inoculated with 5000 M. leprae in each hind foot pad were subjected to nerve conduction velocity studies followed by light and electron microscopy and fibre tease of both sciatic nerves at sequential time intervals from the 4th to the 24th month. The conduction velocity was standardized for basal temperature of 35 degrees C and uninoculated mice were used as controls. Progressive changes were noted in conduction velocity from the 6th post inoculation month and correlated with the ultrastructural changes which were first observed at the 4th month. Fibre teasing showed predominent segmental demyelination.
BT - Leprosy in India C1 - http://www.ncbi.nlm.nih.gov/pubmed/6991814?dopt=Abstract CN - Infolep Library - available DA - 1980 Jan IS - 1 J2 - Lepr India LA - eng N2 -Non-immunosuppressed Swiss mice inoculated with 5000 M. leprae in each hind foot pad were subjected to nerve conduction velocity studies followed by light and electron microscopy and fibre tease of both sciatic nerves at sequential time intervals from the 4th to the 24th month. The conduction velocity was standardized for basal temperature of 35 degrees C and uninoculated mice were used as controls. Progressive changes were noted in conduction velocity from the 6th post inoculation month and correlated with the ultrastructural changes which were first observed at the 4th month. Fibre teasing showed predominent segmental demyelination.
PY - 1980 SP - 26 EP - 47 T2 - Leprosy in India TI - Study of evolution of nerve damage in leprosy. Part III--Sciatic nerve lesions in mice inoculated with M. leprae with nerve conduction velocity correlates. VL - 52 SN - 0024-1024 ER -