TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Female
KW - Humans
KW - Immunity, Cellular
KW - leprosy
KW - Male
KW - Middle Aged
KW - Rosette Formation
KW - T-Lymphocytes
AU - Lim S D
AU - Woo C S
AU - Youn J I
AU - Kim Y W
AU - Kim D I
AU - FUSARO R M
AB - <p>The authors quantitated T-rosette-forming cell (TRFC) and T-cell subsets (T mu, T gamma) in the peripheral blood of twenty patients with lepromatous leprosy. The results obtained in their studies are as follows: (1) They reconfirmed the low levels of TRFC in patients with lepromatous type of leprosy; (2) T-cell subsets, both T mu (helper) and T gamma (suppressor) cells, showed lower levels in all patients with lepromatous leprosy than mean values of normal healthy controls; (3) The degree of decreased levels of T mu cells (96%) was more severe than other parameters TRFC (70%) and T gamma cells (47%) in all patients with lepromatous leprosy; and (4) It may be concluded that the alteration of the T-cell subset, T mu-cells, reflects a more fundamental abnormality than TRFC aberration in demonstrating the impairment of cell-mediated immunity in patients with lepromatous leprosy.</p>
BT - International journal of dermatology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6983504?dopt=Abstract
DA - 1982 Oct
DO - 10.1111/j.1365-4362.1982.tb03182.x
IS - 8
J2 - Int. J. Dermatol.
LA - eng
N2 - <p>The authors quantitated T-rosette-forming cell (TRFC) and T-cell subsets (T mu, T gamma) in the peripheral blood of twenty patients with lepromatous leprosy. The results obtained in their studies are as follows: (1) They reconfirmed the low levels of TRFC in patients with lepromatous type of leprosy; (2) T-cell subsets, both T mu (helper) and T gamma (suppressor) cells, showed lower levels in all patients with lepromatous leprosy than mean values of normal healthy controls; (3) The degree of decreased levels of T mu cells (96%) was more severe than other parameters TRFC (70%) and T gamma cells (47%) in all patients with lepromatous leprosy; and (4) It may be concluded that the alteration of the T-cell subset, T mu-cells, reflects a more fundamental abnormality than TRFC aberration in demonstrating the impairment of cell-mediated immunity in patients with lepromatous leprosy.</p>
PY - 1982
SP - 458
EP - 64
T2 - International journal of dermatology
TI - Leprosy. XII. T-cell subsets in lepromatous leprosy.
VL - 21
SN - 0011-9059
ER -