TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Antibodies, Bacterial
KW - Antigens, Bacterial
KW - BCG Vaccine
KW - Child
KW - Enzyme-Linked Immunosorbent Assay
KW - Female
KW - Humans
KW - leprosy
KW - Male
KW - Mannans
KW - Middle Aged
KW - Mycobacterium
KW - Polysaccharides
KW - Tuberculosis, Pulmonary
AU - Miller R A
AU - Dissanayake S
AU - Buchanan T M
AB - <p>A carbohydrate antigen composed predominantly of arabinomannan has been purified from Mycobacterium smegmatis and used in an enzyme-linked immunosorbent assay to detect anti-mycobacterial antibodies in human sera. Sera from 117 controls, 25 tuberculosis patients, 124 leprosy patients and 256 household contacts of leprosy patients were tested. When compared with the control group, 56% of tuberculosis patients, 27% of patients with tuberculoid leprosy, 77% of borderline leprosy cases, and 95% of patients with lepromatous leprosy had elevated titers. Nine percent of the household contact group had abnormally high levels of antibody. The relevance of these findings to the serodiagnosis of incubating leprosy and the management of household contacts of leprosy patients is discussed.</p>
BT - The American journal of tropical medicine and hygiene
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6859401?dopt=Abstract
DA - 1983 May
DO - 10.4269/ajtmh.1983.32.555
IS - 3
J2 - Am. J. Trop. Med. Hyg.
LA - eng
N2 - <p>A carbohydrate antigen composed predominantly of arabinomannan has been purified from Mycobacterium smegmatis and used in an enzyme-linked immunosorbent assay to detect anti-mycobacterial antibodies in human sera. Sera from 117 controls, 25 tuberculosis patients, 124 leprosy patients and 256 household contacts of leprosy patients were tested. When compared with the control group, 56% of tuberculosis patients, 27% of patients with tuberculoid leprosy, 77% of borderline leprosy cases, and 95% of patients with lepromatous leprosy had elevated titers. Nine percent of the household contact group had abnormally high levels of antibody. The relevance of these findings to the serodiagnosis of incubating leprosy and the management of household contacts of leprosy patients is discussed.</p>
PY - 1983
SP - 555
EP - 64
T2 - The American journal of tropical medicine and hygiene
TI - Development of an enzyme-linked immunosorbent assay using arabinomannan from Mycobacterium smegmatis: a potentially useful screening test for the diagnosis of incubating leprosy.
VL - 32
SN - 0002-9637
ER -