TY - JOUR
KW - Adolescent
KW - Adult
KW - Aminopyrine N-Demethylase
KW - Antipyrine
KW - Bilirubin
KW - Biopsy, Needle
KW - Chloramphenicol
KW - Female
KW - Glucuronosyltransferase
KW - Humans
KW - leprosy
KW - Liver
KW - Male
KW - Middle Aged
AU - Kumar B
AU - Narang A P
AU - Koshy A
AU - Sharma S C
AU - Kaur S
AB - <p>Plasma antipyrine and chloramphenicol clearance was studied in 23 patients of leprosy and 12 control subjects. Drug metabolising enzymes (aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase) were estimated in liver biopsy samples of twelve patients and ten controls. A significant decrease in drug clearance and drug metabolising enzymes was observed. However, no significant correlation could be obtained between drug half lives and drug metabolising enzymes or with any of the liver function tests in these patients. The findings indicate that drug metabolism is impaired in leprosy patients.</p>
BT - Leprosy in India
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6808244?dopt=Abstract
CN - Infolep Library - available
DA - 1982 Jan
IS - 1
J2 - Lepr India
LA - eng
N2 - <p>Plasma antipyrine and chloramphenicol clearance was studied in 23 patients of leprosy and 12 control subjects. Drug metabolising enzymes (aminopyrine N-demethylase and bilirubin UDP-glucuronyl transferase) were estimated in liver biopsy samples of twelve patients and ten controls. A significant decrease in drug clearance and drug metabolising enzymes was observed. However, no significant correlation could be obtained between drug half lives and drug metabolising enzymes or with any of the liver function tests in these patients. The findings indicate that drug metabolism is impaired in leprosy patients.</p>
PY - 1982
SP - 75
EP - 81
T2 - Leprosy in India
TI - In vivo and in vitro drug metabolism in patients with leprosy.
VL - 54
SN - 0024-1024
ER -