TY - JOUR
KW - Antibodies
KW - Apoptosis
KW - Calcium Signaling
KW - Cells, Cultured
KW - Humans
KW - Interleukin-2
KW - Ionomycin
KW - leprosy
KW - Leprosy, lepromatous
KW - Leprosy, Tuberculoid
KW - Leukocytes, Mononuclear
KW - Monensin
KW - Tumor Necrosis Factor-alpha
KW - Zinc
AU - Gupta A
AU - Sharma V K
AU - Vohra H
AU - Ganguly N K
AB - <p>PBMC from tuberculoid (BT/TT) and lepromatous leprosy (BL/LL) leprosy patients showed spontaneous apoptosis when cultured in the absence of mitogen for 24 h, which was inhibited by anti-tumour necrosis factor-alpha (TNF-alpha) antibodies. Apoptosis was also inhibited by ionomycin and zinc, which also increased IL-2 and decreased TNF-alpha production. The increase in IL-2 production suggests a mechanism whereby dietary supplements with zinc might alter the cell-mediated immunity response in leprosy patients.</p>
BT - Clinical and experimental immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/10403916?dopt=Abstract
DA - 1999 Jul
DO - 10.1046/j.1365-2249.1999.00908.x
IS - 1
J2 - Clin. Exp. Immunol.
LA - eng
N2 - <p>PBMC from tuberculoid (BT/TT) and lepromatous leprosy (BL/LL) leprosy patients showed spontaneous apoptosis when cultured in the absence of mitogen for 24 h, which was inhibited by anti-tumour necrosis factor-alpha (TNF-alpha) antibodies. Apoptosis was also inhibited by ionomycin and zinc, which also increased IL-2 and decreased TNF-alpha production. The increase in IL-2 production suggests a mechanism whereby dietary supplements with zinc might alter the cell-mediated immunity response in leprosy patients.</p>
PY - 1999
SP - 56
EP - 62
T2 - Clinical and experimental immunology
TI - Inhibition of apoptosis by ionomycin and zinc in peripheral blood mononuclear cells (PBMC) of leprosy patients.
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC1905487/pdf/cei0117-0056.pdf
VL - 117
SN - 0009-9104
ER -