Hydrocortisone production was studied in 36 patients with lepromatous leprosy before and after insulin load as a stress factor using a competitive radioassay. Twenty-three patients showed a so-called paradoxical type of hydrocortisone production suggestive of markedly exhausted hydrocortisone-producing function of the adrenal cortex. Reserve hydrocortisone production was depressed in most of the patients with active disease; while cured patients showed a partial restoration in reserve hydrocortisone production. Leprosy relapses seem to be among the factors affecting the reserve hydrocortisone-producing function of adrenals. The question of reassessment of the principles of steroid therapy in lepromatous patients with relapses is raised.
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association C1 -http://www.ncbi.nlm.nih.gov/pubmed/6683255?dopt=Abstract
DA - 1983 Mar IS - 1 J2 - Int. J. Lepr. Other Mycobact. Dis. LA - eng N2 -Hydrocortisone production was studied in 36 patients with lepromatous leprosy before and after insulin load as a stress factor using a competitive radioassay. Twenty-three patients showed a so-called paradoxical type of hydrocortisone production suggestive of markedly exhausted hydrocortisone-producing function of the adrenal cortex. Reserve hydrocortisone production was depressed in most of the patients with active disease; while cured patients showed a partial restoration in reserve hydrocortisone production. Leprosy relapses seem to be among the factors affecting the reserve hydrocortisone-producing function of adrenals. The question of reassessment of the principles of steroid therapy in lepromatous patients with relapses is raised.
PY - 1983 SP - 18 EP - 21 T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association TI - Hydrocortisone production in lepromatous patients with insulin load. UR - http://ila.ilsl.br/pdfs/v51n1a03.pdf VL - 51 SN - 0148-916X ER -