TY - JOUR
KW - Humans
KW - Langerhans Cells
KW - leprosy
KW - Microscopy, Electron
KW - Skin
AU - Mathur N K
AU - Agarwal U S
AU - Mangal H N
AU - Bedwal R S
AU - Mathur R S
AU - Bajpai V K
AU - Shipstone A C
AB - <p>ATPase staining and ultrastructural study of skin biopsies from six patients of leprosy (2TT, 4LL) and three normal subjects was carried out to study Langherhans Cells (LC). ATPase staining showed normal counts of LCs in tuberculoid patients, while significant reduction was observed in lepromatous cases. Electron microscopy revealed morphological changes in LL cases in the form of dense matrix and indistinct cristae of mitochondria; decreased number of lysosomes and rough endoplasmic reticulum; and numerous vacuoles in cytoplasm. TT cases showed normal morphology. Possible role of Langerhans Cells in pathogenesis of leprosy is discussed.</p>
BT - Indian journal of leprosy
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6549454?dopt=Abstract
CN - Infolep Library - available
DA - 1984 Oct-Dec
IS - 4
J2 - Indian J Lepr
LA - eng
N2 - <p>ATPase staining and ultrastructural study of skin biopsies from six patients of leprosy (2TT, 4LL) and three normal subjects was carried out to study Langherhans Cells (LC). ATPase staining showed normal counts of LCs in tuberculoid patients, while significant reduction was observed in lepromatous cases. Electron microscopy revealed morphological changes in LL cases in the form of dense matrix and indistinct cristae of mitochondria; decreased number of lysosomes and rough endoplasmic reticulum; and numerous vacuoles in cytoplasm. TT cases showed normal morphology. Possible role of Langerhans Cells in pathogenesis of leprosy is discussed.</p>
PY - 1984
SP - 840
EP - 3
T2 - Indian journal of leprosy
TI - Ultrastructural study of epidermal Langherhans cells in leprosy.
VL - 56
SN - 0254-9395
ER -