TY - JOUR
KW - Antigens, Bacterial
KW - Cell Communication
KW - Cells, Cultured
KW - Colchicine
KW - Histocompatibility Antigens Class II
KW - HLA-DR Antigens
KW - Humans
KW - leprosy
KW - Lymphocytes
KW - Macrophages
KW - Mycobacterium
KW - Mycobacterium leprae
KW - Trypsin
AU - Birdi T J
AU - Mistry N F
AU - Mahadevan P R
AU - Antia N H
AB - <p>Peripheral blood derived macrophages from lepromatous leprosy patients were unable to interact with lymphocytes in the presence of M. leprae. This lack of interaction is probably not associated with membrane HLA-Dr antigens since trypsin and colchicine restored M. leprae induced depression in the latter but were unable to bring about a positive interaction. Two possible defects exist therefore in the lepromatous macrophage. These are an innate inability to process and present M. leprae antigens to lymphocytes and an induced inability to express some membrane receptors, an event detrimental to the normal functioning of a macrophage.</p>
BT - Journal of clinical & laboratory immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6376810?dopt=Abstract
DA - 1984 Apr
IS - 4
J2 - J Clin Lab Immunol
LA - eng
N2 - <p>Peripheral blood derived macrophages from lepromatous leprosy patients were unable to interact with lymphocytes in the presence of M. leprae. This lack of interaction is probably not associated with membrane HLA-Dr antigens since trypsin and colchicine restored M. leprae induced depression in the latter but were unable to bring about a positive interaction. Two possible defects exist therefore in the lepromatous macrophage. These are an innate inability to process and present M. leprae antigens to lymphocytes and an induced inability to express some membrane receptors, an event detrimental to the normal functioning of a macrophage.</p>
PY - 1984
SP - 189
EP - 94
T2 - Journal of clinical & laboratory immunology
TI - Antigen specific macrophage-lymphocyte interaction in lepromatous leprosy.
VL - 13
SN - 0141-2760
ER -