TY - JOUR KW - Animals KW - Concanavalin A KW - Female KW - Immunity, Cellular KW - Killer Cells, Natural KW - leprosy KW - Lymphocyte Activation KW - Macrophages KW - Mice KW - Mice, Inbred BALB C KW - Mice, Inbred C3H KW - Mycobacterium leprae AU - Ridel P R AU - Jhol J S AU - Krahenbuhl J L AB -

Following treatment of BALB/c or C3H/HeN mice in the hind footpads with irradiated Mycobacterium leprae, a marked enhancement of natural killer (NK) activity was observed in cells from the draining popliteal lymph node or from the spleen. NK activity was further enhanced when the treatment consisted of killed M. leprae which had been incorporated into mouse peritoneal macrophages. This effect was noted as early as 2 weeks after treatment and persisted for at least 9 weeks. Lymphoblastic transformation in response to suboptimal doses of the T-cell mitogen transformation in response to suboptimal doses of the T-cell mitogen concanavalin A or to M. leprae antigen was assayed in parallel in cells from the draining popliteal lymph node and from the spleen. In contrast to NK assays, treatment with M. leprae alone moderately altered the response to mitogen. However, there was a prominent enhancement of the T-cell response when treatment consisted of M. leprae-laden macrophages.

BT - Annales d'immunologie C1 - http://www.ncbi.nlm.nih.gov/pubmed/6385816?dopt=Abstract DA - 1984 Jul-Aug DO - 10.1016/s0769-2625(84)80153-1 IS - 1 J2 - Ann. Immunol. (Paris) LA - eng N2 -

Following treatment of BALB/c or C3H/HeN mice in the hind footpads with irradiated Mycobacterium leprae, a marked enhancement of natural killer (NK) activity was observed in cells from the draining popliteal lymph node or from the spleen. NK activity was further enhanced when the treatment consisted of killed M. leprae which had been incorporated into mouse peritoneal macrophages. This effect was noted as early as 2 weeks after treatment and persisted for at least 9 weeks. Lymphoblastic transformation in response to suboptimal doses of the T-cell mitogen transformation in response to suboptimal doses of the T-cell mitogen concanavalin A or to M. leprae antigen was assayed in parallel in cells from the draining popliteal lymph node and from the spleen. In contrast to NK assays, treatment with M. leprae alone moderately altered the response to mitogen. However, there was a prominent enhancement of the T-cell response when treatment consisted of M. leprae-laden macrophages.

PY - 1984 SP - 39 EP - 50 T2 - Annales d'immunologie TI - Cell-mediated immunity in mice treated with Mycobacterium leprae or with macrophages harbouring M. leprae. VL - 135D SN - 0300-4910 ER -