TY - JOUR
KW - Adjuvants, Immunologic
KW - Animals
KW - Antigens, Bacterial
KW - Female
KW - Glycolipids
KW - Hypersensitivity, Delayed
KW - Immunity, Cellular
KW - Inflammation
KW - leprosy
KW - Lymph Nodes
KW - Mice
KW - Mice, Inbred CBA
KW - Mycobacterium leprae
KW - Vaccination
AU - Brett S J
AU - Lowe C
AU - Payne S N
AU - Draper P
AB - <p>The involvement of the phenolic glycolipid from Mycobacterium leprae in cell-mediated immunity has been investigated in this study. The phenolic glycolipid itself does not appear to stimulate cell-mediated immunity directly, as shown by its failure to elicit a classical delayed-type hypersensitivity response in mice immunized with M. leprae or to stimulate M. leprae-immune lymph node cells in a lymphoproliferative assay. Intradermal vaccination with the phenolic glycolipid failed to influence the growth of M. leprae in mouse footpads. A nonspecific inflammatory response to the sonicated glycolipid was observed in mice vaccinated with whole M. leprae and in control animals. No evidence was obtained for any adjuvant or suppressive effect on cell-mediated immunity by the phenolic glycolipid either to M. leprae or an unrelated antigen (sheep erythrocytes); neither sensitization nor elicitation to either antigen was affected.</p>
BT - Infection and immunity
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6389362?dopt=Abstract
DA - 1984 Dec
IS - 3
J2 - Infect. Immun.
LA - eng
N2 - <p>The involvement of the phenolic glycolipid from Mycobacterium leprae in cell-mediated immunity has been investigated in this study. The phenolic glycolipid itself does not appear to stimulate cell-mediated immunity directly, as shown by its failure to elicit a classical delayed-type hypersensitivity response in mice immunized with M. leprae or to stimulate M. leprae-immune lymph node cells in a lymphoproliferative assay. Intradermal vaccination with the phenolic glycolipid failed to influence the growth of M. leprae in mouse footpads. A nonspecific inflammatory response to the sonicated glycolipid was observed in mice vaccinated with whole M. leprae and in control animals. No evidence was obtained for any adjuvant or suppressive effect on cell-mediated immunity by the phenolic glycolipid either to M. leprae or an unrelated antigen (sheep erythrocytes); neither sensitization nor elicitation to either antigen was affected.</p>
PY - 1984
SP - 802
EP - 8
T2 - Infection and immunity
TI - Phenolic glycolipid 1 of Mycobacterium leprae causes nonspecific inflammation but has no effect on cell-mediated responses in mice.
VL - 46
SN - 0019-9567
ER -