TY - JOUR
KW - Animals
KW - Chromosome Mapping
KW - Crosses, Genetic
KW - Disease Susceptibility
KW - Female
KW - Immunity, Innate
KW - Male
KW - Mice
KW - Mice, Inbred A
KW - Mice, Inbred BALB C
KW - Mice, Inbred C57BL
KW - Mice, Inbred DBA
KW - Mycobacterium Infections
KW - Mycobacterium bovis
KW - Mycobacterium lepraemurium
KW - Recombination, Genetic
AU - Skamene E
AU - Gros P
AU - Forget A
AU - Patel P J
AU - Nesbitt M N
AB - <p>Mice of different inbred strains vary in their resistance to intravenous infection with Mycobacterium lepraemurium (MLM). The mean survival time of MLM-infected A/J and DBA/2 mice is significantly longer than that of similarly infected C57BL/6 and BALB/c mice. The typing of AXB/BXA recombinant inbred strains (A = A/J,B = C57BL/6) for the trait of relative resistance/susceptibility to MLM revealed a perfect match with the strain distribution pattern of resistance/susceptibility to Mycobacterium bovis (BCG), the trait which is controlled by the Bcg (Ity, Lsh) locus on chromosome 1. The control, by this gene, of response to MLM was further confirmed by the demonstration that BALB/c-Bcgr congenic mice, which carry the DBA/2-derived Bcgr (resistant) allele on chromosome 1, are significantly more resistant to MLM infection than their BALB/c (Bcgs, susceptible) counterparts.</p>
BT - Immunogenetics
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6365754?dopt=Abstract
DA - 1984
DO - 10.1007/bf00387854
IS - 2
J2 - Immunogenetics
LA - eng
N2 - <p>Mice of different inbred strains vary in their resistance to intravenous infection with Mycobacterium lepraemurium (MLM). The mean survival time of MLM-infected A/J and DBA/2 mice is significantly longer than that of similarly infected C57BL/6 and BALB/c mice. The typing of AXB/BXA recombinant inbred strains (A = A/J,B = C57BL/6) for the trait of relative resistance/susceptibility to MLM revealed a perfect match with the strain distribution pattern of resistance/susceptibility to Mycobacterium bovis (BCG), the trait which is controlled by the Bcg (Ity, Lsh) locus on chromosome 1. The control, by this gene, of response to MLM was further confirmed by the demonstration that BALB/c-Bcgr congenic mice, which carry the DBA/2-derived Bcgr (resistant) allele on chromosome 1, are significantly more resistant to MLM infection than their BALB/c (Bcgs, susceptible) counterparts.</p>
PY - 1984
SP - 117
EP - 24
T2 - Immunogenetics
TI - Regulation of resistance to leprosy by chromosome 1 locus in the mouse.
VL - 19
SN - 0093-7711
ER -