An immunofluorescent study was carried out on skin biopsies from 12 leprosy patients who had been suffering from the disease for periods of one to 30 years; all were treated with dapsone and clofazimine at one stage. Skin biopsies made from reactive nodular lesions showed that all 12 had IgG deposits and seven had IgM deposits in the dermal-epidermal junction. No IgA, IgE, C3 and fibrinogen were found deposited in any biopsy. All patients had significantly raised levels of serum immunoglobulins and rheumatoid factor. Anti-epithelial (eight patients) and anti-nuclear (three patients) antibodies were also found. The possible role of autoantibodies in the present findings is discussed.
BT - Annals of tropical medicine and parasitology C1 - http://www.ncbi.nlm.nih.gov/pubmed/6349556?dopt=Abstract DA - 1983 Feb DO - 10.1080/00034983.1983.11811676 IS - 1 J2 - Ann Trop Med Parasitol LA - eng N2 -An immunofluorescent study was carried out on skin biopsies from 12 leprosy patients who had been suffering from the disease for periods of one to 30 years; all were treated with dapsone and clofazimine at one stage. Skin biopsies made from reactive nodular lesions showed that all 12 had IgG deposits and seven had IgM deposits in the dermal-epidermal junction. No IgA, IgE, C3 and fibrinogen were found deposited in any biopsy. All patients had significantly raised levels of serum immunoglobulins and rheumatoid factor. Anti-epithelial (eight patients) and anti-nuclear (three patients) antibodies were also found. The possible role of autoantibodies in the present findings is discussed.
PY - 1983 SP - 87 EP - 94 T2 - Annals of tropical medicine and parasitology TI - Immunoglobulin deposits in leprosy skin. VL - 77 SN - 0003-4983 ER -