TY - JOUR
KW - Adult
KW - Animals
KW - Cells, Cultured
KW - Dapsone
KW - Female
KW - Humans
KW - In Vitro Techniques
KW - leprosy
KW - Macrophages
KW - Male
KW - Mice
KW - Mycobacterium leprae
KW - Thymidine
AU - Mittal A
AU - Sathish M
AU - Seshadri P S
AU - Nath I
AB - <p>This paper describes a microculture rapid assay using radiolabeling and mouse macrophages to determine the viability and the drug susceptibility or resistance of Mycobacterium leprae. Comparison of M. leprae resident macrophage cultures maintained in 96-well flat-bottomed plates showed results for viability and susceptibility or resistance to dapsone that were similar to results for concurrent cultures in Leighton tubes with greater numbers of bacilli and macrophages.</p>
BT - Journal of clinical microbiology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6343428?dopt=Abstract
DA - 1983 Apr
IS - 4
J2 - J. Clin. Microbiol.
LA - eng
N2 - <p>This paper describes a microculture rapid assay using radiolabeling and mouse macrophages to determine the viability and the drug susceptibility or resistance of Mycobacterium leprae. Comparison of M. leprae resident macrophage cultures maintained in 96-well flat-bottomed plates showed results for viability and susceptibility or resistance to dapsone that were similar to results for concurrent cultures in Leighton tubes with greater numbers of bacilli and macrophages.</p>
PY - 1983
SP - 704
EP - 7
T2 - Journal of clinical microbiology
TI - Rapid, radiolabeled-microculture method that uses macrophages for in vitro evaluation of Mycobacterium leprae viability and drug susceptibility.
UR - https://www.ncbi.nlm.nih.gov/pmc/articles/PMC272723/pdf/jcm00141-0158.pdf
VL - 17
SN - 0095-1137
ER -