Non-culturable acid-fast bacteria from two spontaneous cases of so-called feline leprosy were transmitted to rats and cats and further passaged in rats or cats. Two to six months after infection, cats developed cutaneous lesions that were indistinguishable from spontaneous cases, including the occurrence of nasal granulomata in one cat. When injected into rats, the mycobacteria caused a generalized mycobacteriosis and the granulomatous reaction was composed chiefly of macrophages without polymorphonuclear granulocytes. Infection of cats with Mycobacterium lepraemurium did not produce any lesions. The feline disease may be a suitable model for the study of human leprosy (Hansen's Disease).
BT - Veterinary pathology C1 - http://www.ncbi.nlm.nih.gov/pubmed/6353741?dopt=Abstract CN - SCHIEFER1983 DA - 1983 Jul DO - 10.1177/030098588302000409 IS - 4 J2 - Vet. Pathol. LA - eng N2 -Non-culturable acid-fast bacteria from two spontaneous cases of so-called feline leprosy were transmitted to rats and cats and further passaged in rats or cats. Two to six months after infection, cats developed cutaneous lesions that were indistinguishable from spontaneous cases, including the occurrence of nasal granulomata in one cat. When injected into rats, the mycobacteria caused a generalized mycobacteriosis and the granulomatous reaction was composed chiefly of macrophages without polymorphonuclear granulocytes. Infection of cats with Mycobacterium lepraemurium did not produce any lesions. The feline disease may be a suitable model for the study of human leprosy (Hansen's Disease).
PY - 1983 SP - 460 EP - 71 T2 - Veterinary pathology TI - Experimental transmission of a feline mycobacterial skin disease (feline leprosy). UR - http://vet.sagepub.com/content/20/4/460.full.pdf+html VL - 20 SN - 0300-9858 ER -