In the sera of patients with lepromatous leprosy anti-DNP antibodies were detected in order to determine the mode of polyclonal B-cell activation. Anti-DNP antibodies were found in 30% of the patients with active lepromatous leprosy and in 8% of those with inactive lepromatous leprosy. The level of anti-DNP antibodies in active patients was significantly higher than the level in inactive patients and control. However, the presence of anti-DNP antibodies was unrelated to the production of circulating immune complexes and antinuclear antibodies. These results suggest that polyclonal B-cell activation might occur but that the B-cell clones stimulated by M. leprae are different from patient to patient.
BT - Archives of dermatological research C1 - http://www.ncbi.nlm.nih.gov/pubmed/6332578?dopt=Abstract DA - 1984 DO - 10.1007/bf00414019 IS - 3 J2 - Arch. Dermatol. Res. LA - eng N2 -In the sera of patients with lepromatous leprosy anti-DNP antibodies were detected in order to determine the mode of polyclonal B-cell activation. Anti-DNP antibodies were found in 30% of the patients with active lepromatous leprosy and in 8% of those with inactive lepromatous leprosy. The level of anti-DNP antibodies in active patients was significantly higher than the level in inactive patients and control. However, the presence of anti-DNP antibodies was unrelated to the production of circulating immune complexes and antinuclear antibodies. These results suggest that polyclonal B-cell activation might occur but that the B-cell clones stimulated by M. leprae are different from patient to patient.
PY - 1984 SP - 195 EP - 8 T2 - Archives of dermatological research TI - Anti-hapten antibodies and autoantibodies in Japanese patients with lepromatous leprosy. VL - 276 SN - 0340-3696 ER -