TY - JOUR
KW - Adolescent
KW - Adult
KW - Dapsone
KW - Dose-Response Relationship, Drug
KW - Female
KW - Humans
KW - Hypersensitivity, Delayed
KW - leprosy
KW - Male
KW - Middle Aged
KW - Neuritis
KW - Prospective Studies
AU - Barnetson R S
AU - Pearson J M
AU - Rees R J
AB - <p>68 patients were included in a prospective study of the treatment of borderline leprosy. 34 were treated with dapsone 5 mg daily, and 34 with 50 mg daily. Reversal reactions developed in 11 of those on 5 mg daily and in 3 of those on 50 mg daily. The statistically significant difference between the two treatment groups indicates that, contrary to previous teaching, dapsone given in higher dosage does not predispose patients to reversal reactions and indeed may prevent them.</p>
BT - Lancet (London, England)
C1 - http://www.ncbi.nlm.nih.gov/pubmed/62998?dopt=Abstract
DA - 1976 Nov 27
DO - 10.1016/s0140-6736(76)91684-6
IS - 7996
J2 - Lancet
LA - eng
N2 - <p>68 patients were included in a prospective study of the treatment of borderline leprosy. 34 were treated with dapsone 5 mg daily, and 34 with 50 mg daily. Reversal reactions developed in 11 of those on 5 mg daily and in 3 of those on 50 mg daily. The statistically significant difference between the two treatment groups indicates that, contrary to previous teaching, dapsone given in higher dosage does not predispose patients to reversal reactions and indeed may prevent them.</p>
PY - 1976
SP - 1171
EP - 2
T2 - Lancet (London, England)
TI - Evidence for prevention of borderline leprosy reactions by dapsone.
VL - 2
SN - 0140-6736
ER -