TY - JOUR KW - Adult KW - Ceroid KW - Clofazimine KW - Dapsone KW - Drug Therapy, Combination KW - Histocytochemistry KW - Humans KW - leprosy KW - Macrophages KW - Male KW - Peripheral nerves KW - Peripheral Nervous System Diseases KW - Pigmentation Disorders KW - Pigments, Biological KW - Rifampin AU - McDougall A C AU - Jones R L AB -

A 33 year old male Nigerian presented with widespread involvement of peripheral nerves, several of which were tender and painful. Nerve biopsies confirmed the presence of Mycobacterium leprae in both endoneurial and perineurial areas, mainly in foamy macrophages (Virchow cells), but there were also large accumulations of an amorphous, acid-fast and alcohol-fast material which was not obviously of bacterial origin. Appropriate stains indicated that this had many characteristics of lipofuscin. Although not previously known, it was at this stage discovered that the patient had received treatment with anti-leprosy drugs nearly three years before presentation in this country. One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.

BT - Journal of neurology, neurosurgery, and psychiatry C1 - http://www.ncbi.nlm.nih.gov/pubmed/6260900?dopt=Abstract DA - 1981 Feb DO - 10.1136/jnnp.44.2.116 IS - 2 J2 - J. Neurol. Neurosurg. Psychiatry LA - eng N2 -

A 33 year old male Nigerian presented with widespread involvement of peripheral nerves, several of which were tender and painful. Nerve biopsies confirmed the presence of Mycobacterium leprae in both endoneurial and perineurial areas, mainly in foamy macrophages (Virchow cells), but there were also large accumulations of an amorphous, acid-fast and alcohol-fast material which was not obviously of bacterial origin. Appropriate stains indicated that this had many characteristics of lipofuscin. Although not previously known, it was at this stage discovered that the patient had received treatment with anti-leprosy drugs nearly three years before presentation in this country. One of these was clofazimine, an aniline aposafranine derivative known to produce a ceroid-like pigment in the tissues of patients treated with this drug or lepromatous leprosy.

PY - 1981 SP - 116 EP - 20 T2 - Journal of neurology, neurosurgery, and psychiatry TI - Intra-neural ceroid-like pigment following the treatment of lepromatous leprosy with clofazimine (B663; Lamprene). VL - 44 SN - 0022-3050 ER -