TY - JOUR
KW - Antibodies, Monoclonal
KW - Fluorescent Antibody Technique
KW - Histocompatibility Antigens Class II
KW - HLA-DR Antigens
KW - Humans
KW - leprosy
KW - Macrophages
KW - Mycobacterium leprae
KW - Phenotype
KW - Skin
KW - T-Lymphocytes
KW - T-Lymphocytes, Helper-Inducer
KW - T-Lymphocytes, Regulatory
AU - Van Voorhis W C
AU - Kaplan G
AU - Sarno E N
AU - Horwitz M A
AU - Steinman R M
AU - Levis W R
AU - Nogueira N
AU - Hair L S
AU - Gattass C R
AU - Arrick B A
AU - Cohn Z A
AB - <p>We report on the characteristics of cells in the cutaneous lesions and blood of 21 patients with lepromatous, tuberculoid, and intermediate forms of leprosy. A large proportion of the infiltrates in lepromatous lesions consist of macrophages heavily parasitized with Mycobacterium leprae. The T cells in the lesions are devoid of OKT4/Leu 3a-positive ("helper") cells and consist almost exclusively of OKT8/Leu 2a-positive ("suppressor") populations. In contrast, the tuberculoid infiltrates contain well-organized epithelioid and giant-cell granulomas and only remnants of bacilli, and the predominant T cell is from the OKT4/Leu 3a-positive subset. In both tuberculoid and lepromatous infiltrates, T cells and macrophages expressed HLA-DR antigen. No marked alteration in the distribution of blood T-cell phenotypes was noted. We conclude that there is a marked difference between T-cell subsets in lepromatous and tuberculoid infiltrates, which may influence the microbicidal activity of macrophages in the lesions.</p>
BT - The New England journal of medicine
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6216407?dopt=Abstract
DA - 1982 Dec 23
DO - 10.1056/NEJM198212233072601
IS - 26
J2 - N. Engl. J. Med.
LA - eng
N2 - <p>We report on the characteristics of cells in the cutaneous lesions and blood of 21 patients with lepromatous, tuberculoid, and intermediate forms of leprosy. A large proportion of the infiltrates in lepromatous lesions consist of macrophages heavily parasitized with Mycobacterium leprae. The T cells in the lesions are devoid of OKT4/Leu 3a-positive ("helper") cells and consist almost exclusively of OKT8/Leu 2a-positive ("suppressor") populations. In contrast, the tuberculoid infiltrates contain well-organized epithelioid and giant-cell granulomas and only remnants of bacilli, and the predominant T cell is from the OKT4/Leu 3a-positive subset. In both tuberculoid and lepromatous infiltrates, T cells and macrophages expressed HLA-DR antigen. No marked alteration in the distribution of blood T-cell phenotypes was noted. We conclude that there is a marked difference between T-cell subsets in lepromatous and tuberculoid infiltrates, which may influence the microbicidal activity of macrophages in the lesions.</p>
PY - 1982
SP - 1593
EP - 7
T2 - The New England journal of medicine
TI - The cutaneous infiltrates of leprosy: cellular characteristics and the predominant T-cell phenotypes.
VL - 307
SN - 0028-4793
ER -