TY - JOUR KW - Adolescent KW - Adult KW - Aged KW - Child KW - Child, Preschool KW - Connective Tissue KW - Female KW - Glycosaminoglycans KW - Humans KW - Hyaluronic Acid KW - leprosy KW - Male KW - Middle Aged AU - Sakuntala R AU - Pratap V K AU - Sharma N K AU - Dayal S S AB -

Uniform accumulation of acid mucopolysaccharides in all types of leprosy lesions was seen, except late tuberculoid lesions which showed the accumulation only at the periphery. Absence of acid mucopolysaccharides was significant in well formed epithelioid granulomas and in giant cells of late tuberculoid cases. Generally a progressive decrease with advancing chronicity of the disease was noted. The dermal zone without any cellular infiltrate showed abundant acid mucopolysaccharides in comparison to those areas having inflammatory cell infiltrate in 70.83% of LL, 42.86% of BL, 33.3% of BB, 40.0% of BT, and 13.51% of TT cases. In Indeterminate cases the distribution was same to that of control cases. Testicular hyaluronidase digestion established that hyaluronic acid constituted the main bulk of acid mucopolysaccharides. The possible source of hyaluronic acid is discussed.

BT - Leprosy in India C1 - http://www.ncbi.nlm.nih.gov/pubmed/6226826?dopt=Abstract CN - Infolep Library - available DA - 1983 Apr IS - 2 J2 - Lepr India LA - eng N2 -

Uniform accumulation of acid mucopolysaccharides in all types of leprosy lesions was seen, except late tuberculoid lesions which showed the accumulation only at the periphery. Absence of acid mucopolysaccharides was significant in well formed epithelioid granulomas and in giant cells of late tuberculoid cases. Generally a progressive decrease with advancing chronicity of the disease was noted. The dermal zone without any cellular infiltrate showed abundant acid mucopolysaccharides in comparison to those areas having inflammatory cell infiltrate in 70.83% of LL, 42.86% of BL, 33.3% of BB, 40.0% of BT, and 13.51% of TT cases. In Indeterminate cases the distribution was same to that of control cases. Testicular hyaluronidase digestion established that hyaluronic acid constituted the main bulk of acid mucopolysaccharides. The possible source of hyaluronic acid is discussed.

PY - 1983 SP - 252 EP - 60 T2 - Leprosy in India TI - Acid mucopolysaccharides in leprosy lesions. VL - 55 SN - 0024-1024 ER -