TY - JOUR
KW - Adult
KW - Concanavalin A
KW - Erythema Nodosum
KW - Female
KW - Humans
KW - leprosy
KW - Lymphocyte Activation
KW - Male
KW - Middle Aged
KW - Phytohemagglutinins
KW - T-Lymphocytes, Regulatory
AU - Sasiain M C
AU - Ruibal Ares B
AU - Baliña L M
AU - Valdez R
AU - Bachmann A E
AB - <p>ConA-induced suppressor activity in patients with lepromatous leprosy (LL) was studied. Patients were studied during and after erythema nodosum leprosum (ENL) reactions. The study included 16 patients with ENL, nine of whom returned once the ENL episode was over. Patients were compared to 12 normal controls. Suppressor activity was evaluated in vitro by cultivating peripheral blood lymphocytes (PBL) with an inducer of T suppressor cells, concanavalin A (ConA), and with two different mitogens, phytohemagglutinin (PHA) and ConA, in order to measure the inhibition of the proliferative responses in all cases. In contrast, in LL patients during ENL the ConA-induced suppressor response was markedly reduced. The reduction in suppressor responses was even more marked in the LL patients after the ENL episode. Reduced levels of suppressor activity in LL patients reveal a defect in central mechanisms of control in the immune response.</p>
BT - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6227570?dopt=Abstract
DA - 1983 Sep
IS - 3
J2 - Int. J. Lepr. Other Mycobact. Dis.
LA - eng
N2 - <p>ConA-induced suppressor activity in patients with lepromatous leprosy (LL) was studied. Patients were studied during and after erythema nodosum leprosum (ENL) reactions. The study included 16 patients with ENL, nine of whom returned once the ENL episode was over. Patients were compared to 12 normal controls. Suppressor activity was evaluated in vitro by cultivating peripheral blood lymphocytes (PBL) with an inducer of T suppressor cells, concanavalin A (ConA), and with two different mitogens, phytohemagglutinin (PHA) and ConA, in order to measure the inhibition of the proliferative responses in all cases. In contrast, in LL patients during ENL the ConA-induced suppressor response was markedly reduced. The reduction in suppressor responses was even more marked in the LL patients after the ENL episode. Reduced levels of suppressor activity in LL patients reveal a defect in central mechanisms of control in the immune response.</p>
PY - 1983
SP - 321
EP - 7
T2 - International journal of leprosy and other mycobacterial diseases : official organ of the International Leprosy Association
TI - ConA-induced suppressor cells in lepromatous leprosy patients during and after erythema nodosum leprosum.
VL - 51
SN - 0148-916X
ER -