TY - JOUR
KW - Adolescent
KW - Adult
KW - Aged
KW - Cytotoxicity, Immunologic
KW - Erythema Nodosum
KW - Humans
KW - leprosy
KW - Lymphocyte Activation
KW - Lymphocyte Culture Test, Mixed
KW - Middle Aged
KW - T-Lymphocytes
AU - Stach J L
AU - Strobel M
AU - Fumoux F
AU - Bach J F
AB - <p>Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL) are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.</p>
BT - Clinical and experimental immunology
C1 - http://www.ncbi.nlm.nih.gov/pubmed/6214342?dopt=Abstract
DA - 1982 Jun
IS - 3
J2 - Clin. Exp. Immunol.
LA - eng
N2 - <p>Cytotoxic T cells are consistently produced in normal individuals after in vitro stimulation by a pool of mitomycin-treated normal lymphocytes. Patients suffering from lepromatous leprosy (LL), presenting with large amounts of Mycobacterium leprae and without a history of erythema nodosum leprosum (ENL) are unable to generate such cytotoxic T cells, while lepromatous patients with ENL which, in the present study were all deprived of M. leprae, react normally.</p>
PY - 1982
SP - 633
EP - 40
T2 - Clinical and experimental immunology
TI - Defect in the generation of cytotoxic T cells in lepromatous leprosy.
VL - 48
SN - 0009-9104
ER -